Guilbaud G, Benoist J M, Gautron M, Kayser V
Unité de Recherches de Neurophysiologie Pharmacologique de l'I.N.S.E.R.M. (U. 161), 2, rue d'Alésia, 75014 Paris France.
Pain. 1982 Jun;13(2):153-163. doi: 10.1016/0304-3959(82)90025-2.
This study dealt with the effect of aspirin upon activities of 17 ventrobasal thalamic neurons recorded in 17 rats rendered arthritic by injection of Freund's adjuvant into the tail. These neurons presented reproducible responses to mobilization and/or mild lateral pressure on a joint and were recorded for at least 40 min after aspirin administration. After intravenous injection of aspirin at the dose of 50 mg/kg (13 neurons tested), there was a progressive decrease in the number of spikes in the discharges. The maximum effect occurred at 30 min where the mean value of the response expressed as a percentage of the control was m = 34.62 +/- 7.5% (n = 13, p less than or equal to 0.001). Recovery was progressive and could be considered as complete at 60 min. By contrast, no significant modification of the spontaneous firing has been observed. With lower doses of aspirin (12.5 or 25 mg/kg tested with 4 neurons) there was respectively no clear depressive effect or only a transient decrease of the response.
本研究探讨了阿司匹林对17只通过向尾部注射弗氏佐剂而患关节炎的大鼠中记录的17个腹侧基底丘脑神经元活动的影响。这些神经元对关节的活动和/或轻度侧向压力呈现可重复的反应，并在给予阿司匹林后至少记录40分钟。静脉注射50mg/kg剂量的阿司匹林后（测试了13个神经元），放电中的尖峰数量逐渐减少。最大效应出现在30分钟时，以对照的百分比表示的反应平均值为m = 34.62 +/- 7.5%（n = 13，p≤0.001）。恢复是渐进的，60分钟时可认为恢复完全。相比之下，未观察到自发放电有明显改变。使用较低剂量的阿司匹林（用4个神经元测试12.5或25mg/kg）时，分别没有明显的抑制作用或只是反应短暂下降。
