Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Building 49 Room 1B80, 49 Convent Drive MSC 4415, Bethesda, MD 20892-4415, USA.
Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Building 49 Room 1B80, 49 Convent Drive MSC 4415, Bethesda, MD 20892-4415, USA; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA; Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, USA.
Cell Rep. 2022 Jan 4;38(1):110198. doi: 10.1016/j.celrep.2021.110198.
Goal-directed behavior requires identifying objects in the environment that can satisfy internal needs and executing actions to obtain those objects. The current study examines ventral and dorsal corticostriatal circuits that support complementary aspects of goal-directed behavior. We analyze activity from the amygdala, ventral striatum, orbitofrontal cortex, and lateral prefrontal cortex (LPFC) while monkeys perform a three-armed bandit task. Information about chosen stimuli and their value is primarily encoded in the amygdala, ventral striatum, and orbitofrontal cortex, while the spatial information is primarily encoded in the LPFC. Before the options are presented, information about the to-be-chosen stimulus is represented in the amygdala, ventral striatum, and orbitofrontal cortex; at the time of choice, the information is passed to the LPFC to direct a saccade. Thus, learned value information specifying behavioral goals is maintained throughout the ventral corticostriatal circuit, and it is routed through the dorsal circuit at the time actions are selected.
目标导向行为需要识别环境中的物体，这些物体可以满足内部需求，并执行获取这些物体的行动。本研究考察了支持目标导向行为互补方面的腹侧和背侧皮质纹状体回路。当猴子执行三臂赌博任务时，我们分析了杏仁核、腹侧纹状体、眶额皮层和外侧前额叶皮层（LPFC）的活动。关于所选刺激及其价值的信息主要编码在杏仁核、腹侧纹状体和眶额皮层中，而空间信息主要编码在 LPFC 中。在呈现选项之前，关于要选择的刺激的信息在杏仁核、腹侧纹状体和眶额皮层中被表示；在选择时，信息被传递到 LPFC 以引导扫视。因此，指定行为目标的习得价值信息在整个腹侧皮质纹状体回路中得以维持，并且在选择行动时通过背侧回路进行传递。
