Departments of Molecular Biosciences, Chemistry, and the Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA.
Nucleic Acids Res. 2022 Jan 7;50(D1):D526-D533. doi: 10.1093/nar/gkab1086.
The Human Proteoform Atlas (HPfA) is a web-based repository of experimentally verified human proteoforms on-line at http://human-proteoform-atlas.org and is a direct descendant of the Consortium of Top-Down Proteomics' (CTDP) Proteoform Atlas. Proteoforms are the specific forms of protein molecules expressed by our cells and include the unique combination of post-translational modifications (PTMs), alternative splicing and other sources of variation deriving from a specific gene. The HPfA uses a FAIR system to assign persistent identifiers to proteoforms which allows for redundancy calling and tracking from prior and future studies in the growing community of proteoform biology and measurement. The HPfA is organized around open ontologies and enables flexible classification of proteoforms. To achieve this, a public registry of experimentally verified proteoforms was also created. Submission of new proteoforms can be processed through email vianrtdphelp@northwestern.edu, and future iterations of these proteoform atlases will help to organize and assign function to proteoforms, their PTMs and their complexes in the years ahead.
人类蛋白组肽图谱（HPfA）是一个基于网络的人类蛋白组肽实验验证数据库，网址为 http://human-proteoform-atlas.org，它是自上而下的蛋白质组学联盟（CTDP）蛋白组肽图谱的直接衍生产品。蛋白肽是我们细胞表达的蛋白质分子的特定形式，包括翻译后修饰（PTMs）、选择性剪接和其他源自特定基因的变异来源的独特组合。HPfA 使用 FAIR 系统为蛋白肽分配持久标识符，允许从不断增长的蛋白肽生物学和测量研究社区中的先前和未来研究中进行冗余调用和跟踪。HPfA 围绕开放本体组织，并能够灵活地对蛋白肽进行分类。为此，还创建了一个经过实验验证的蛋白肽公共注册中心。通过电子邮件 vianrtdphelp@northwestern.edu 提交新的蛋白肽，这些蛋白肽图谱的未来迭代将有助于在未来几年对蛋白肽、它们的 PTMs 和复合物进行组织和功能分配。
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