CHU Lille, Institut de Biologie de la Reproduction-Spermiologie-CECOS, Jeanne de Flandre Hospital, Lille, France.
Inserm UMR-S 1172, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille, France.
Reprod Biol Endocrinol. 2022 Jan 5;20(1):7. doi: 10.1186/s12958-021-00874-2.
The primary objective of the present study of women participating in an ICSI program was to determine whether the morphologic quality of oocytes was related to the polycystic ovary syndrome (PCOS) phenotype.
We performed a retrospective cohort study in the IVF unit at the Lille University Medical Center (Lille, France) between 2006 and 2015. Oocyte morphology (fragmented first polar body, abnormal zona pellucida, large perivitelline space, material in perivitelline space, abnormal shape of oocyte, granular cytoplasm and intracytoplasmic vacuoles) was evaluated in PCOS women and according to different subgroup (depending on the presence or absence of the cardinal features polycystic ovarian morphology (PCOM), hyperandrogenism (HA), and oligo-anovulation (OA)).
A total of 1496 metaphase II oocytes (n = 602 for phenotype A combining PCOM + HA + OA, n = 462 oocytes for phenotype C: PCOM + HA, and n = 432 for phenotype D: PCOM + OA) were assessed. The phenotypes A, C and D did not differ significantly with regard to the proportion of normal oocytes (adjusted percentages (95%CI): 35.2% (31.5 to 39.1%), 25.8% (21.9 to 29.9%) and 34.0% (29.7 to 38.6%), respectively: adjusted p = 0.13). Likewise, there were no significant intergroup differences in oocyte morphology. The ICSI outcome was not significantly associated with the PCOS phenotype.
The present study is the first to show that the PCOS phenotype (notably the presence vs. absence of OA and/or HA) is not significantly associated with the morphological quality of oocytes.
本研究旨在探讨参与卵胞浆内单精子注射（ICSI）项目的女性中，卵母细胞形态质量是否与多囊卵巢综合征（PCOS）表型相关。
我们在法国里尔大学医疗中心（里尔）的 IVF 中心进行了一项回顾性队列研究，研究时间为 2006 年至 2015 年。评估了 PCOS 女性的卵母细胞形态（第一极体碎片化、透明带异常、大卵周隙、卵周隙物质、卵母细胞形状异常、颗粒状胞质和胞质内空泡），并根据不同亚组（是否存在多囊卵巢形态（PCOM）、高雄激素血症（HA）和少排卵（OA）的主要特征）进行了评估。
共评估了 1496 枚成熟 II 期卵母细胞（表型 A 组 PCOM+HA+OA 结合，n=602；表型 C 组 PCOM+HA，n=462；表型 D 组 PCOM+OA，n=432）。表型 A、C 和 D 在正常卵母细胞的比例方面没有显著差异（调整后的百分比（95%CI）：35.2%（31.5 至 39.1%）、25.8%（21.9 至 29.9%）和 34.0%（29.7 至 38.6%），调整后的 p=0.13）。同样，卵母细胞形态在各组间也没有显著差异。ICSI 结局与 PCOS 表型无显著相关性。
本研究首次表明，PCOS 表型（特别是 OA 和/或 HA 的存在与否）与卵母细胞的形态质量无显著相关性。
