Fathi Azar Elahe, Hosseinzadeh Samaneh, Nosrat Abadi Masoud, Sayad Nasiri Mohamad, Haghgoo Hojjat Allah
MSc in Occupational Therapy, The University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Biostatics Department, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Hong Kong J Occup Ther. 2021 Dec;34(2):121-131. doi: 10.1177/15691861211065155. Epub 2021 Dec 20.
The most common cognitive dysfunctions in patients with schizophrenia are information processing, memory, and learning. Based on the hypothesis of rehabilitation and brain stimulation in memory and learning, adding a form of neuromodulation to conventional rehabilitation might increase the effectiveness of treatments.
To explore the effects of psychosocial occupational therapy combined with anodal Transcranial Direct Current Stimulation (tDCS) on cognitive performance in patients with Schizophrenia.
Twenty-four patients diagnosed with schizophrenia were randomized into the experimental and control groups. We used The Cambridge Neuropsychological Test Automated Battery (CANTAB) and the Loewenstein Occupational Therapy Cognitive Assessment battery (LOTCA) to assess spatial recognition, attention, visual memory, learning abilities, and high-level cognitive functions like problem-solving. All participants received customized psychosocial occupational therapy activities. Furthermore, the experimental group received 12 sessions of active anodal tDCS for 20 minutes with 2 mA intensity on the left dorsolateral prefrontal cortex (DLPFC) while the patients in the sham group received sham tDCS.
Combining tDCS to conventional psychosocial occupational therapy resulted in a significant increase in spatial memory, visual learning, and attention.
Anodal tDCS on the left DLPFC improved visual memory, attention, and learning abilities. Contrary to our expectations, we could not find any changes in complex and more demanding cognitive functions.
精神分裂症患者最常见的认知功能障碍是信息处理、记忆和学习。基于记忆和学习方面的康复及脑刺激假说，在传统康复治疗中加入一种神经调节形式可能会提高治疗效果。
探讨心理社会职业治疗联合阳极经颅直流电刺激（tDCS）对精神分裂症患者认知表现的影响。
将24例诊断为精神分裂症的患者随机分为实验组和对照组。我们使用剑桥神经心理测试自动成套系统（CANTAB）和洛温斯坦职业治疗认知评估量表（LOTCA）来评估空间识别、注意力、视觉记忆、学习能力以及解决问题等高级认知功能。所有参与者均接受定制的心理社会职业治疗活动。此外，实验组在左侧背外侧前额叶皮质（DLPFC）接受12次20分钟、强度为2毫安的阳极tDCS治疗，而假手术组患者接受假tDCS治疗。
将tDCS与传统心理社会职业治疗相结合可显著提高空间记忆、视觉学习和注意力。
左侧DLPFC的阳极tDCS改善了视觉记忆、注意力和学习能力。与我们的预期相反，我们未发现复杂且要求更高的认知功能有任何变化。
