Key Laboratory of Environmental Health, Ministry of Education, Department of Toxicology, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
School of Basic Medicine, Health Science Center, Yangtze University, 1 Nanhuan Road, Jingzhou, Hubei 434023, China.
Theranostics. 2022 Jan 1;12(1):87-104. doi: 10.7150/thno.64096. eCollection 2022.
Exosomes are multifunctional regulators of intercellular communication by carrying various messages under both physiological and pathological status of cancer patients. Accumulating studies have identified the presence of circular RNAs (circRNAs) in exosomes with crucial regulatory roles in diverse pathophysiological processes. Exosomal circRNAs derived from donor cells can modulate crosstalk with recipient cells locally or remotely to enhance cancer development and propagation, and play crucial roles in the tumor microenvironment (TME), leading to significant enhancement of tumor immunity, metabolism, angiogenesis, drug resistance, epithelial mesenchymal transition (EMT), invasion and metastasis. In this review, we describe the advances of exosomal circRNAs and their roles in modulating cancer hallmarks, especially those in the TME. Moreover, clinical application potential of exosomal circRNAs in cancer diagnosis and therapy are highlighted, bridging the gap between basic knowledge and clinical practice.
外泌体是细胞间通讯的多功能调节剂，在癌症患者的生理和病理状态下携带各种信息。越来越多的研究已经确定了外泌体中环状 RNA（circRNA）的存在，它们在外泌体中具有重要的调节作用，参与多种病理生理过程。来自供体细胞的外泌体 circRNA 可以调节与受体细胞的局部或远程串扰，以增强癌症的发展和传播，并在肿瘤微环境（TME）中发挥关键作用，导致肿瘤免疫、代谢、血管生成、耐药性、上皮间质转化（EMT）、侵袭和转移的显著增强。在这篇综述中，我们描述了外泌体 circRNA 的进展及其在调节癌症特征中的作用，特别是在 TME 中的作用。此外，还强调了外泌体 circRNA 在癌症诊断和治疗中的临床应用潜力，弥合了基础知识和临床实践之间的差距。
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