文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

缺氧响应型超分子制剂用于影像引导光热治疗。

A hypoxia-responsive supramolecular formulation for imaging-guided photothermal therapy.

机构信息

College of Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), State Key Laboratory of Elemento-Organic Chemistry, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Nankai University, Tianjin 300071, China.

Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Chinese Academy of Medical Sciences, Institute of Radiation Medicine Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300192, China.

出版信息

Theranostics. 2022 Jan 1;12(1):396-409. doi: 10.7150/thno.67036. eCollection 2022.

DOI:10.7150/thno.67036
PMID:34987652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8690909/
Abstract

Photothermal agents (PTAs) based on organic small-molecule dyes emerge as promising theranostic strategy in imaging and photothermal therapy (PTT). However, hydrophobicity, photodegradation, and low signal-to-noise ratio impede their transformation from bench to bedside. In this study, a novel supramolecular PTT formulation by a stimuli-responsive macrocyclic host is prepared to overcome these obstacles of organic small-molecule PTAs. Sulfonated azocalix[4]arene (SAC4A) was synthesized as a hypoxia-responsive macrocyclic host. Taking IR780 as an example, the supramolecular nanoformulation IR780@SAC4A was constructed by grinding method, and its solubility, photostability, and photothermal conversion were evaluated. The hypoxia tumor-selective imaging and supramolecular PTT of IR780@SAC4A were further evaluated and . IR780@SAC4A is capable of enhancing the solubility, photostability, and photothermal conversion of IR780 significantly, which achieve this supramolecular formulation with good imaging-guided PTT efficacy and . This study demonstrates that the supramolecular PTT strategy is a promising cancer theranostic method. Moreover, this supramolecular approach is applicative to construct kinds of supramolecular PTAs, opening a general avenue for extending smart PTT formulations.

摘要

基于有机小分子染料的光热剂 (PTAs) 作为一种有前途的成像和光热治疗 (PTT) 治疗策略而出现。然而，疏水性、光降解和低信噪比阻碍了它们从实验室向临床的转化。在这项研究中，通过响应性大环主体制备了一种新型的刺激响应超分子 PTT 制剂，以克服有机小分子 PTA 的这些障碍。合成磺化杯[4]芳烃 (SAC4A) 作为缺氧响应性大环主体。以 IR780 为例，通过研磨法构建了超分子纳米制剂 IR780@SAC4A，并对其溶解度、光稳定性和光热转换进行了评价。进一步评价了 IR780@SAC4A 的缺氧肿瘤选择性成像和超分子 PTT。IR780@SAC4A 能够显著提高 IR780 的溶解度、光稳定性和光热转换效率，使这种超分子制剂具有良好的成像指导 PTT 疗效。该研究表明，超分子 PTT 策略是一种很有前途的癌症治疗方法。此外，这种超分子方法适用于构建各种超分子 PTA，为扩展智能 PTT 制剂开辟了一条通用途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b00/8690909/d386673d8a43/thnov12p0396g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b00/8690909/6cce5c062e35/thnov12p0396g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b00/8690909/fab704f1f858/thnov12p0396g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b00/8690909/a21e39068802/thnov12p0396g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b00/8690909/60ff2c4be571/thnov12p0396g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b00/8690909/7032845cfd79/thnov12p0396g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b00/8690909/d386673d8a43/thnov12p0396g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b00/8690909/6cce5c062e35/thnov12p0396g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b00/8690909/fab704f1f858/thnov12p0396g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b00/8690909/a21e39068802/thnov12p0396g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b00/8690909/60ff2c4be571/thnov12p0396g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b00/8690909/7032845cfd79/thnov12p0396g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b00/8690909/d386673d8a43/thnov12p0396g006.jpg

相似文献

[1]
A hypoxia-responsive supramolecular formulation for imaging-guided photothermal therapy.

Theranostics. 2022

[2]
Pd@Au Bimetallic Nanoplates Decorated Mesoporous MnO for Synergistic Nucleus-Targeted NIR-II Photothermal and Hypoxia-Relieved Photodynamic Therapy.

Adv Healthc Mater. 2020-1

[3]
Multifunctional phototheranostic nanoplatform based on polydopamine-manganese dioxide-IR780 iodide for effective magnetic resonance imaging-guided synergistic photodynamic/photothermal therapy.

J Colloid Interface Sci. 2022-4

[4]
NIR/MRI-Guided Oxygen-Independent Carrier-Free Anti-Tumor Nano-Theranostics.

Small. 2022-9

[5]
Recent Development of Photothermal Agents (PTAs) Based on Small Organic Molecular Dyes.

Chembiochem. 2020-8-3

[6]
In Situ Hypoxia-Induced Supramolecular Perylene Diimide Radical Anions in Tumors for Photothermal Therapy with Improved Specificity.

J Am Chem Soc. 2022-2-9

[7]
All organic nanomedicine for PDT-PTT combination therapy of cancer cells in hypoxia.

Sci Rep. 2024-7-30

[8]
Nanococktail Based on AIEgens and Semiconducting Polymers: A Single Laser Excited Image-Guided Dual Photothermal Therapy.

Theranostics. 2020

[9]
Bone-targeted erythrocyte-cancer hybrid membrane-camouflaged nanoparticles for enhancing photothermal and hypoxia-activated chemotherapy of bone invasion by OSCC.

J Nanobiotechnology. 2021-10-26

[10]
Programmable multistage small-molecule nano-photosensitizer for multimodal imaging-guided photothermal therapy.

Acta Biomater. 2023-2

引用本文的文献

[1]
Co-delivery paclitaxel and IR783 as nanoparticles for potentiated chemo-photothermal-immunotherapy of triple-negative breast cancer.

Mater Today Bio. 2025-6-16

[2]
Supramolecular discrimination and diagnosis-guided treatment of intracellular bacteria.

Nat Commun. 2025-1-25

[3]
De novo strategy of organic semiconducting polymer brushes for NIR-II light-triggered carbon monoxide release to boost deep-tissue cancer phototheranostics.

J Nanobiotechnology. 2024-11-14

[4]
Supramolecular nanomedicine in the intelligent cancer therapy: recent advances and future.

Front Pharmacol. 2024-10-11

[5]
Theranostic Fluorescent Probes.

Chem Rev. 2024-3-13

[6]
A light-activatable theranostic combination for ratiometric hypoxia imaging and oxygen-deprived drug activity enhancement.

Nat Commun. 2024-1-2

[7]
Exosomes with IR780 and Lenvatinib loaded on GPC3 single-chain scFv antibodies for targeted hyperthermia and chemotherapy in hepatocellular carcinoma therapy.

Am J Cancer Res. 2023-11-15

[8]
Dual hypoxia-responsive supramolecular complex for cancer target therapy.

Nat Commun. 2023-9-13

[9]
Dual Stimuli-Responsive Micelles for Imaging-Guided Mitochondrion-Targeted Photothermal/Photodynamic/Chemo Combination Therapy-Induced Immunogenic Cell Death.

Int J Nanomedicine. 2023

[10]
Immune cell membrane-based biomimetic nanomedicine for treating cancer metastasis.

Acta Pharm Sin B. 2023-6

本文引用的文献

[1]
Fluorescent Supramolecular Polymers Based on Pillar[5]arene for OLED Device Fabrication.

ACS Macro Lett. 2017-7-18

[2]
Cucurbit[10]uril-Encapsulated Cationic Porphyrins with Enhanced Fluorescence Emission and Photostability for Cell Imaging.

ACS Appl Mater Interfaces. 2021-1-20

[3]
Improved cancer phototheranostic efficacy of hydrophobic IR780 via parenteral route by association with tetrahedral nanostructured DNA.

J Control Release. 2021-2-10

[4]
Nanomaterials with Supramolecular Assembly Based on AIE Luminogens for Theranostic Applications.

Adv Mater. 2020-12

[5]
A Self-Degradable Supramolecular Photosensitizer with High Photodynamic Therapeutic Efficiency and Improved Safety.

Angew Chem Int Ed Engl. 2021-1-11

[6]
Labeling PLA-PEG nanocarriers with IR780: physical entrapment versus covalent attachment to polylactide.

Drug Deliv Transl Res. 2020-12

[7]
A General Hypoxia-Responsive Molecular Container for Tumor-Targeted Therapy.

Adv Mater. 2020-7

[8]
Constructing Adaptive Photosensitizers via Supramolecular Modification Based on Pillararene Host-Guest Interactions.

Angew Chem Int Ed Engl. 2020-7-13

[9]
Recent Development of Photothermal Agents (PTAs) Based on Small Organic Molecular Dyes.

Chembiochem. 2020-8-3

[10]
Supramolecular prodrugs based on host-guest interactions.

Chem Soc Rev. 2020-3-17

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索