Li Shuo, Wang Yujiao, Li Chao, Zhou Binghao, Zeng Xiaoxi, Zhu Hong
Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Front Pharmacol. 2024 Oct 11;15:1490139. doi: 10.3389/fphar.2024.1490139. eCollection 2024.
In recent years, the incidence of cancer has been increasing year by year, and the burden of the disease and the economic burden caused by it has been worsening. Although chemotherapy, immunotherapy, targeted therapy and other therapeutic means continue to progress, they still inevitably have problems such as high toxicity and side effects, susceptibility to drug resistance, and high price. Photothermal therapy and photodynamic therapy have demonstrated considerable advantages in cancer imaging and treatment due to their minimally invasive and selective nature. However, their development has been constrained by challenges related to drug delivery. In recent times, drug delivery systems constructed based on supramolecular chemistry have been the subject of considerable interest, particularly in view of their compatibility with the high permeability and long retention effect of tumors. Furthermore, the advantage of dissociating the active ingredient under pH, light and other stimuli makes them unique in cancer therapy. This paper reviews the current status of supramolecular nanomedicines in cancer therapy, elucidating the challenges faced and providing a theoretical basis for the efficient and precise treatment of malignant tumors.
近年来，癌症发病率逐年上升，疾病负担及其所致的经济负担不断加重。尽管化疗、免疫疗法、靶向治疗等治疗手段不断进步，但仍不可避免地存在毒性和副作用大、易产生耐药性、价格高昂等问题。光热疗法和光动力疗法因其微创性和选择性，在癌症成像和治疗方面显示出相当大的优势。然而，它们的发展受到药物递送相关挑战的限制。近年来，基于超分子化学构建的药物递送系统备受关注，特别是鉴于它们与肿瘤的高渗透性和长滞留效应的兼容性。此外，在pH、光等刺激下解离活性成分的优势使其在癌症治疗中独树一帜。本文综述了超分子纳米药物在癌症治疗中的现状，阐明了面临的挑战，并为恶性肿瘤的高效精准治疗提供理论依据。
