Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, Connecticut 06269, USA.
Org Biomol Chem. 2022 Jan 19;20(3):667-671. doi: 10.1039/d1ob02187g.
A methodology for the preparation of nitriles from aldehydes by means of an oxidative functionalisation reaction is reported. It employs ammonium persulfate as both the primary oxidant and the nitrogen source, and a catalytic amount of a nitroxide. It is applicable to a range of structurally diverse (hetero)aromatic aldehydes furnishing the nitrile products in 30-97% isolated yield. Given the ready accessibility of aldehydes and that ammonium persulfate is cheap and less toxic than many other reagents for generating nitriles, this methodology offers a simple and easy to use approach to this valuable class of compounds.
本文报道了一种通过氧化官能化反应由醛制备腈的方法。它采用过硫酸铵作为主要氧化剂和氮源，并使用催化量的氮氧自由基。该方法适用于一系列结构多样的（杂）芳族醛，以 30-97%的分离收率得到腈产物。鉴于醛的易得性以及过硫酸铵比许多其他用于生成腈的试剂便宜且毒性更小，因此该方法为这类有价值的化合物提供了一种简单易用的方法。
