Huang Zhenhuan, Tu Xuezhao, Lin Qi, Zhan Zejuan, Li Ying, Liu Jinkai
Department of Radiology, Longyan First Affiliated Hospital of Fujian Medical University, No. 105 North 91 Road, Xinluo District, Fujian 364000, China.
Department of Orthopedics, Longyan First Affiliated Hospital of Fujian Medical University, No. 105 North 91 Road, Xinluo District, Fujian 364000, China.
Clin Imaging. 2022 Mar;83:77-82. doi: 10.1016/j.clinimag.2021.12.013. Epub 2021 Dec 30.
To retrospectively investigate whether magnetic resonance imaging (MRI) quantitative parameters can differentiate human epidermal growth factor receptor 2 (HER2) status in rectal cancer.
This study included 89 patients with surgically confirmed rectal cancer who underwent preoperative MRI from June 2014 to May 2019. Patients were divided into three groups: HER2 negative (HER2-Neg); HER2-low expression (HER2-L); and HER2 positive (HER2-Pos). Quantitative perfusion parameters derived from dynamic contrast-enhanced MRI (DCE-MRI) Tofts model (pharmacokinetic blood dual compartment model) were listed as follows: volume transfer constant (K), rate constant (K), and extracellular volume ratio (V). The mean, minimum, and maximum apparent diffusion coefficient (ADC) values at standard (800 s/mm) b-values were obtained with diffusion-weighted imaging (DWI). Clinicopathologic characteristics and quantitative parameters were compared by Fisher's exact test and one-way analysis of variance (ANOVA), respectively.
The 89 patients included 52 (58.4%) with HER2-Neg, 31 (34.8%) with HER2-L, and 6 (6.8%) with HER2-Pos states. Fisher's exact test showed that clinicopathologic characteristics among the three groups were not significantly different (p = 0.281 to 1.000). Likewise, there were no associations between HER2 status and any quantitative parameters, including K (p = 0.296), K (p = 0.290), V (p = 0.184), ADC (p = 0.181), ADC (p = 0.143), or ADC (p = 0.058).
Quantitative perfusion parameters (K, K, V) and ADC values were not able to discriminate HER2 status in patients with rectal cancer or evaluate treatment response in real time.
回顾性研究磁共振成像（MRI）定量参数能否区分直肠癌中人表皮生长因子受体2（HER2）状态。
本研究纳入了89例经手术确诊的直肠癌患者，这些患者在2014年6月至2019年5月期间接受了术前MRI检查。患者分为三组：HER2阴性（HER2-Neg）；HER2低表达（HER2-L）；以及HER2阳性（HER2-Pos）。源自动态对比增强MRI（DCE-MRI）Tofts模型（药代动力学血液双室模型）的定量灌注参数如下：容积转运常数（K）、速率常数（K）和细胞外容积比（V）。通过扩散加权成像（DWI）获得标准（800 s/mm²）b值下的平均、最小和最大表观扩散系数（ADC）值。分别采用Fisher精确检验和单因素方差分析（ANOVA）比较临床病理特征和定量参数。
89例患者中，HER2-Neg状态者52例（58.4%），HER2-L状态者31例（34.8%），HER2-Pos状态者6例（6.8%）。Fisher精确检验显示三组间临床病理特征无显著差异（p = 0.281至1.000）。同样，HER2状态与任何定量参数之间均无关联，包括K（p = 0.296）、K（p = 0.290）、V（p = 0.184）、ADC（p = 0.181）、ADC（p = 0.143）或ADC（p = 0.058）。
定量灌注参数（K、K、V）和ADC值无法区分直肠癌患者的HER2状态，也无法实时评估治疗反应。
