Barza M, Peckman C, Baum J
Department of Medicine, New England Medical Center, Boston, MA 02111.
Arch Ophthalmol. 1987 Oct;105(10):1418-20. doi: 10.1001/archopht.1987.01060100120040.
We examined the efficacy of transcleral iontophoresis as an adjunct to intravitreal injection in the treatment of experimental Pseudomonas endophthalmitis in rabbits. Animals received no antibacterial treatment (untreated controls; group 1), a single intravitreal injection of 100 micrograms of gentamicin sulfate (group 2), or the same dose of gentamicin sulfate along with two treatments of transscleral iontophoresis given 24 and 48 hours after the intravitreal injection (group 3). Treatment was initiated 16, 24, or 48 hours after the induction of infection. For each interval from infection to treatment, there was a lower bacterial count and a higher rate of sterilization in the eyes in group 3 than in group 2; both treated groups had better outcomes than the untreated controls. These data suggest that transscleral iontophoresis could be clinically useful as a supplement to intravitreal injection for a refractory type of endophthalmitis such as that caused by Pseudomonas aeruginosa.
我们研究了经巩膜离子电渗疗法作为玻璃体内注射辅助手段在治疗兔实验性铜绿假单胞菌性眼内炎中的疗效。动物分为三组：未接受抗菌治疗（未治疗对照组；第1组）、单次玻璃体内注射100微克硫酸庆大霉素（第2组）、或在玻璃体内注射后24小时和48小时给予相同剂量硫酸庆大霉素并进行两次经巩膜离子电渗疗法治疗（第3组）。感染诱导后16、24或48小时开始治疗。对于从感染到治疗的每个时间间隔，第3组眼中的细菌计数低于第2组，杀菌率高于第2组；两个治疗组的结果均优于未治疗对照组。这些数据表明，经巩膜离子电渗疗法作为玻璃体内注射的补充，对于难治性眼内炎（如由铜绿假单胞菌引起的眼内炎）可能具有临床应用价值。
