Barza M, Peckman C, Baum J
Invest Ophthalmol Vis Sci. 1987 Jun;28(6):1033-6.
Experiments in rabbits have shown that the novel technique of transscleral iontophoresis is a safe, effective, noninvasive way to produce high concentrations of antibiotics in the vitreous humor. The authors have now studied the effects of repeated transscleral iontophoresis in the eyes of cynomolgus monkeys. Six treatments with gentamicin sulfate, 1.5 mA for 10 min, were applied to both eyes of three monkeys over a 2-week period. The concentrations of gentamicin in the vitreous humor 24 hr after treatment were determined for each eye on three occasions. The mean concentration was 28 micrograms/ml (range, 11-44 micrograms/ml) after the first treatment and 12 micrograms/ml (range, 2-21 micrograms/ml) after the fifth treatment. Indirect ophthalmoscopy completed after the last treatment showed only small retinal burns up to 2.5 mm in diameter in four eyes in the area of the pars plana over which the electrode had been applied. Electroretinograms were normal after treatment. These experiments confirm the efficacy and safety of transscleral iontophoresis in the primate's eye and suggest that investigations of this potentially useful technique are warranted in humans.
对兔子的实验表明，经巩膜离子电渗疗法这项新技术是一种在玻璃体内产生高浓度抗生素的安全、有效、非侵入性方法。作者现在研究了在食蟹猴眼中重复进行经巩膜离子电渗疗法的效果。在两周时间内，对三只猴子的双眼进行了六次硫酸庆大霉素治疗，电流为1.5毫安，持续10分钟。在三次不同时间点测定了每次治疗后24小时每只眼睛玻璃体内庆大霉素的浓度。第一次治疗后平均浓度为28微克/毫升（范围为11 - 44微克/毫升），第五次治疗后为12微克/毫升（范围为2 - 21微克/毫升）。最后一次治疗后进行的间接检眼镜检查显示，在应用电极的扁平部区域，四只眼睛仅出现直径达2.5毫米的小视网膜烧伤。治疗后视网膜电图正常。这些实验证实了经巩膜离子电渗疗法在灵长类动物眼中的有效性和安全性，并表明对这项潜在有用技术在人类中的研究是有必要的。
