Medicinal Plants Research Institute, Yunnan Academy of Agricultural Sciences, Kunming, China.
College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, China.
Crit Rev Anal Chem. 2023;53(7):1393-1418. doi: 10.1080/10408347.2021.2023460. Epub 2022 Jan 6.
Since ancient times, herbal medicines (HMs) have been widely popular with consumers as a "natural" drug for health care and disease treatment. With the emergence of problems, such as increasing demand for HMs and shortage of resources, it often occurs the phenomenon of shoddy exceed and mixing the false with the genuine in the market. There is an urgent need to evaluate the quality of HMs to ensure their important role in health care and disease treatment, and to reduce the possibility of threat to human health. Modern analytical technology is can be analyzed for analyzing chemical components of HMs or their preparations. Reflecting complex chemical components' characteristic curves in the analysis sample, and the comprehensive effect of active ingredients of HMs. In this review, modern analytical technology (chromatography, spectroscopy, mass spectrometry), chemometrics methods (unsupervised, supervised) and their advantages, disadvantages, and applicability were introduced and summarized. In addition, the authentication application of modern analytical technology combined with chemometrics methods in four aspects, including origin, processing methods, cultivation methods, and adulteration of HMs have also been discussed and illustrated by a few typical studies. This article offers a general workflow of analytical methods that have been applied for HMs authentication and explains that the accuracy of authentication in favor of the quality assurance of HMs. It was provided reference value for the development and application of modern HMs.
自古以来，草药（HM）作为一种“天然”药物，在保健和疾病治疗方面深受消费者欢迎。随着对草药的需求不断增加和资源短缺等问题的出现，市场上经常出现以次充好和以假乱真的现象。迫切需要评估草药的质量，以确保其在保健和疾病治疗中的重要作用，并降低对人类健康造成威胁的可能性。现代分析技术可以分析草药或其制剂的化学成分。反映分析样品中复杂化学成分的特征曲线，以及草药有效成分的综合作用。本文介绍并总结了现代分析技术（色谱、光谱、质谱）、化学计量学方法（无监督、有监督）及其优缺点和适用性。此外，还通过一些典型研究讨论和说明了现代分析技术与化学计量学方法结合在草药产地、加工方法、种植方法和掺假鉴定中的应用。本文提供了一个已应用于草药鉴定的分析方法的一般工作流程，并解释了鉴定的准确性有利于草药质量的保证。为现代草药的开发和应用提供了参考价值。
