Eljaaly Zobeida, Mujammami Muhammad, Nawaz Shaik Sarfaraz, Rafiullah Mohamed, Siddiqui Khalid
University Diabetes Center, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.
Division of Endocrinology, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Diabetes Metab Syndr Obes. 2021 Dec 24;14:4911-4920. doi: 10.2147/DMSO.S344894. eCollection 2021.
Patients with diabetes are at higher risk of the negative consequences of hyperuricemia. The objective of this study was to investigate gender and age-specific differences in the uric acid levels and to evaluate the associated risk factors among patients with diabetes.
A retrospective cross-sectional study was conducted at Strategic Center for Diabetes Research from September 2019 to January 2020, among adult type-2 diabetic patients. Serum uric acid (SUA) and several other metabolic and clinical parameters were examined. Multiple regression analysis was done to identify risk factors independently associated with hyperuricemia.
A total of 433 patients were included in the analysis. SUA level was higher in males than females (5.82±1.65 mg/dL versus 5.29±1.54 mg/dL, p < 0.001). The prevalence of hyperuricemia was higher in females than males (28.8% versus 20.5%, p = 0.049). There was no significant difference in uric acid levels or the prevalence of hyperuricemia by age groups in the total sample or gender-stratified samples. In multivariate analysis, hyperuricemia was associated with bigger hip circumference (odds ratios [OR] were 1.03, 95% CI = 1.01-1.05), higher triglycerides (OR = 1.005, 95% CI = 1.002-1.008), and higher serum creatinine (OR = 1.34, 95% CI = 1.21-1.49). Hip circumference, total cholesterol, high-density lipoprotein, and serum creatinine were independent risk factors in males, while triglycerides and higher serum creatinine were independent risk factors among females.
The present study demonstrates gender-specific differences in the uric acid levels and hyperuricemia prevalence. In males and females, hyperuricemia was associated with hip circumference, total cholesterol, high-density lipoprotein, triglycerides, and serum creatinine. Future large studies are needed to confirm our findings, especially in elderly females.
糖尿病患者发生高尿酸血症不良后果的风险更高。本研究的目的是调查糖尿病患者尿酸水平的性别和年龄特异性差异，并评估相关危险因素。
2019年9月至2020年1月在糖尿病研究战略中心对成年2型糖尿病患者进行了一项回顾性横断面研究。检测了血清尿酸（SUA）及其他一些代谢和临床参数。进行多元回归分析以确定与高尿酸血症独立相关的危险因素。
共有433例患者纳入分析。男性的SUA水平高于女性（5.82±1.65mg/dL对5.29±1.54mg/dL，p<0.001）。女性高尿酸血症的患病率高于男性（28.8%对20.5%，p=0.049）。在总样本或按性别分层的样本中，各年龄组的尿酸水平或高尿酸血症患病率无显著差异。多变量分析显示，高尿酸血症与更大的臀围相关（比值比[OR]为1.03，95%可信区间[CI]=1.01-1.05）、更高的甘油三酯（OR=1.005，95%CI=1.002-1.008）和更高的血清肌酐（OR=1.34，95%CI=1.21-1.49）。臀围、总胆固醇、高密度脂蛋白和血清肌酐是男性的独立危险因素，而甘油三酯和更高的血清肌酐是女性的独立危险因素。
本研究表明尿酸水平和高尿酸血症患病率存在性别特异性差异。在男性和女性中，高尿酸血症与臀围、总胆固醇、高密度脂蛋白、甘油三酯和血清肌酐有关。未来需要进行大型研究来证实我们的发现，尤其是在老年女性中。
