Doyle L W, Nahmias C, Firnau G, Kenyon D B, Garnett E S, Sinclair J C
Dev Med Child Neurol. 1983 Apr;25(2):143-51. doi: 10.1111/j.1469-8749.1983.tb13737.x.
The new diagnostic technique, positron emission tomography with 18F-2-fluoro-2-deoxy-D-glucose (18FDG), was used to measure regional cerebral glucose metabolism in five newborn infants with demonstrated structural abnormalities of the brain. 18FDG was synthesized, diluted in normal saline and injected intravenously. After one hour, tomographic slices of the brain were obtained, the level of the slices being defined relative to the cerebral ventricles. Glucose metabolism of grey- and white-matter structures in the brain could be differentiated clearly. Decreased glucose metabolism was identified in regions of the brain shown by computerized axial tomography to be structurally abnormal. Positron emission tomography is a promising new diagnostic tool for the study of newborn infants with suspected abnormalities of brain function.
采用新的诊断技术——18F - 2 - 氟 - 2 - 脱氧 - D - 葡萄糖正电子发射断层扫描（18FDG），对五名已证实存在脑结构异常的新生儿进行局部脑葡萄糖代谢测定。合成18FDG，用生理盐水稀释后静脉注射。一小时后，获取脑部断层切片，切片水平相对于脑室确定。脑内灰质和白质结构的葡萄糖代谢可清晰区分。在计算机断层扫描显示结构异常的脑区发现葡萄糖代谢降低。正电子发射断层扫描是研究疑似脑功能异常新生儿的一种有前景的新诊断工具。
