Radhakrishnan Sridhar, Yeung Steven F, Ke Jia-Yu, Antunes Maísa M, Pellizzon Michael A
Research Diets, Inc., New Brunswick, NJ, USA.
Center for Gastrointestinal Biology, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Curr Dev Nutr. 2021 Nov 13;5(12):nzab138. doi: 10.1093/cdn/nzab138. eCollection 2021 Dec.
Nonalcoholic fatty liver disease (NAFLD) is intricately linked to metabolic disease (including obesity, glucose intolerance, and insulin resistance) and encompasses a spectrum of disorders including steatosis, nonalcoholic steatohepatitis (NASH), and fibrosis. Rodents consuming high-fat (HF; ∼40 kcal% fat including fats containing higher concentrations of saturated and fats), high-fructose (HFr), and high-cholesterol (HC) diets display many clinically relevant characteristics of NASH, along with other metabolic disorders. C57BL/6 mice are the most commonly used animal model because they can develop significant metabolic disorders including severe NASH with fibrosis after months of feeding, but other models also are susceptible. The significant number of diets that contain these different factors (i.e., HF, HFr, and HC), either alone or in combination, makes the choice of diet difficult. This methodology review describes the efficacy of these nutrient manipulations on the NAFLD phenotype in mice, rats, guinea pigs, hamsters, and nonhuman primates.
非酒精性脂肪性肝病（NAFLD）与代谢性疾病（包括肥胖、葡萄糖不耐受和胰岛素抵抗）有着复杂的联系，涵盖了一系列疾病，包括脂肪变性、非酒精性脂肪性肝炎（NASH）和肝纤维化。食用高脂肪（HF；约40千卡%脂肪，包括含有较高浓度饱和脂肪和不饱和脂肪的脂肪）、高果糖（HFr）和高胆固醇（HC）饮食的啮齿动物表现出许多与NASH临床相关的特征，以及其他代谢紊乱。C57BL/6小鼠是最常用的动物模型，因为它们在喂食数月后会出现严重的代谢紊乱，包括伴有肝纤维化的严重NASH，但其他模型也易受影响。含有这些不同因素（即HF、HFr和HC）的大量饮食，无论是单独还是组合使用，都使得饮食选择变得困难。本方法学综述描述了这些营养干预对小鼠、大鼠、豚鼠、仓鼠和非人灵长类动物NAFLD表型的影响。
