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院外心脏骤停合并心肌梗死管理及结局中的种族差异:一项来自英格兰和威尔士的全国性研究

Racial Disparities in Management and Outcomes of Out-of-Hospital Cardiac Arrest Complicating Myocardial Infarction: A National Study From England and Wales.

作者信息

Dafaalla Mohamed, Rashid Muhammad, Bond Rachel M, Smith Triston, Parwani Purvi, Thamman Ritu, Moledina Saadiq M, Graham Michelle M, Mamas Mamas A

机构信息

Keele Cardiovascular Research Group, School of Medicine, Keele University, Stoke-on-Trent, United Kingdom.

Department of Cardiology, Royal Stoke University Hospital, Stoke-on-Trent, United Kingdom.

出版信息

CJC Open. 2021 Oct 2;3(12 Suppl):S81-S88. doi: 10.1016/j.cjco.2021.09.026. eCollection 2021 Dec.

Abstract

BACKGROUND

Studies of racial disparities in care of patients admitted with an out-of-hospital cardiac arrest (OHCA) in the setting of acute myocardial infarction (AMI) have shown inconsistent results. Whether these differences in care exist in the universal healthcare system in United Kingdom is unknown.

METHODS

Patients admitted with a diagnosis of AMI and OHCA between 2010 and 2017 from the Myocardial Ischaemia National Audit Project (MINAP) were studied. All patients were stratified based on ethnicity into a Black, Asian, or minority ethnicity (BAME) group vs a White group. We used multivariable logistic regression models to evaluate the predictors of clinical outcomes and treatment strategy.

RESULTS

From 14,287 patients admitted with AMI complicated by OHCA, BAME patients constituted a minority of patients (1185 [8.3%]), compared with a White group (13,102 [91.7%]). BAME patients were younger (median age [interquartile range]) for BAME group, 58 [50-70] years; for White group, 65 [55-74] years). Cardiogenic shock (BAME group, 33%; White group, 20.7%; < 0.001) and severe left ventricular impairment (BAME group, 21%; White group, 16.5%; < 0.003) were more frequent among BAME patients. BAME patients were more likely to be seen by a cardiologist (BAME group, 95.9%; White group, 92.5%; < 0.001) and were more likely to receive coronary angiography than the White group (odds ratio [OR] 1.5, 95% confidence interval [CI] 1.2-1.88). The BAME group had significantly higher in-hospital mortality (OR 1.26, 95% CI 1.04-1.52) and re-infarction (OR 1.52, 95% CI 1.06-2.18) than the White group.

CONCLUSIONS

BAME patients were more likely to be seen by a cardiologist and receive coronary angiography than White patients. Despite this difference, the in-hospital mortality of BAME patients, particularly in the Asian population, was significantly higher.

摘要

背景

关于急性心肌梗死(AMI)合并院外心脏骤停(OHCA)患者护理中种族差异的研究结果并不一致。在英国的全民医疗保健系统中是否存在这些护理差异尚不清楚。

方法

对2010年至2017年期间来自心肌缺血国家审计项目(MINAP)的诊断为AMI和OHCA的患者进行研究。所有患者根据种族分为黑人、亚洲人或少数族裔(BAME)组和白人组。我们使用多变量逻辑回归模型来评估临床结局和治疗策略的预测因素。

结果

在14287例诊断为AMI合并OHCA的患者中,BAME患者占少数(1185例[8.3%]),白人组为13102例(91.7%)。BAME患者更年轻(BAME组的中位年龄[四分位间距]为58[50 - 70]岁;白人组为65[55 - 74]岁)。BAME患者发生心源性休克(BAME组为33%;白人组为20.7%;P<0.001)和严重左心室功能障碍(BAME组为21%;白人组为16.5%;P<0.003)的情况更为常见。BAME患者比白人患者更有可能由心脏病专家诊治(BAME组为95.9%;白人组为92.5%;P<0.001),并且比白人组更有可能接受冠状动脉造影(比值比[OR]为1.5,95%置信区间[CI]为1.2 - 1.88)。BAME组的院内死亡率(OR为1.26,95%CI为1.04 - 1.52)和再梗死率(OR为1.52,95%CI为1.06 - 2.18)显著高于白人组。

结论

与白人患者相比,BAME患者更有可能由心脏病专家诊治并接受冠状动脉造影。尽管存在这种差异,但BAME患者,尤其是亚洲人群的院内死亡率显著更高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7dc/8712673/4f19d89aa82b/fx1.jpg

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