秘鲁重症监护病房工作人员的手机和制服上分离出的革兰氏阴性菌中存在令人担忧的抗菌素耐药水平。
Worrying levels of antimicrobial resistance in Gram-negative bacteria isolated from cell phones and uniforms of Peruvian intensive care unit workers.
机构信息
Laboratorio de Genética Molecular y Bioquímica. Universidad Científica del Sur, 15842-Lima, Perú.
Hospital Nacional Dos de Mayo, 15003-Lima, Perú.
出版信息
Trans R Soc Trop Med Hyg. 2022 Jul 6;116(7):676-678. doi: 10.1093/trstmh/trab186.
BACKGROUND
Healthcare worker (HCW) uniforms and cell phones are involved in pathogen transmission. This study aimed to characterize pathogenic microorganism isolates from HCW uniforms and cell phones.
METHODS
Gram-negative microorganisms were recovered from HCW uniforms and cell phones. Antimicrobial susceptibility and the presence of extended-spectrum β-lactamases (ESBL) and carbapenemases were determined.
RESULTS
Escherichia coli was the most prevalent microorganism. Overall, high levels of resistance to cephalosporins, quinolones, co-trimoxazole and colistin were found. ESBL were mainly related to blaCTX-M-15 and blaSHV- genes. Carbapenem-resistant isolates presented as blaKPC or blaNDM.
CONCLUSIONS
High levels of antimicrobial resistance, including colistin, were detected. Therefore, strategies are urgently needed to prevent bacterial dissemination.
背景
医护人员（HCW）制服和手机与病原体传播有关。本研究旨在对 HCW 制服和手机上分离出的致病微生物进行特征描述。
方法
从 HCW 制服和手机上回收革兰氏阴性微生物。测定了其对抗菌药物的敏感性，以及是否存在超广谱β-内酰胺酶（ESBL）和碳青霉烯酶。
结果
大肠埃希菌是最常见的微生物。总体而言，头孢菌素、喹诺酮类、复方磺胺甲噁唑和粘菌素的耐药率很高。ESBL 主要与 blaCTX-M-15 和 blaSHV 基因有关。耐碳青霉烯类的分离株呈现 blaKPC 或 blaNDM 型。
结论
检测到高水平的抗菌药物耐药性，包括粘菌素。因此，迫切需要采取策略来防止细菌传播。
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