Gao Linglin, Chen Xi, Jiang Ziyi, Zhu Jie, Wang Qiang
Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Institute of Infection, Immunology and Tumor Microenvironment, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China.
Microorganisms. 2024 Dec 20;12(12):2653. doi: 10.3390/microorganisms12122653.
Occupational allergic respiratory disease in healthcare workers due to occupational exposure has received widespread attention. At the same time, evidence of altered respiratory flora associated with the development of allergy has been found in relevant epidemiologic studies. It is of concern that the composition of nasopharyngeal flora in healthcare workers differs significantly from that of non-healthcare workers due to occupational factors, with a particularly high prevalence of carriage of pathogenic and drug-resistant bacteria. Recent studies have found that interventions with upper respiratory tract probiotics can significantly reduce the incidence of respiratory allergies and infections. We searched PubMed and other databases to describe the burden of allergic respiratory disease and altered respiratory flora in healthcare workers in this narrative review, and we summarize the mechanisms and current state of clinical research on the use of flora interventions to ameliorate respiratory allergy, with the aim of providing a new direction for protecting the respiratory health of healthcare workers.
职业暴露导致医护人员患职业性过敏性呼吸道疾病已受到广泛关注。与此同时，在相关流行病学研究中发现了与过敏发展相关的呼吸道菌群改变的证据。令人担忧的是，由于职业因素，医护人员的鼻咽菌群组成与非医护人员有显著差异，致病和耐药菌的携带率特别高。最近的研究发现，使用上呼吸道益生菌进行干预可显著降低呼吸道过敏和感染的发生率。在本叙述性综述中，我们检索了PubMed和其他数据库，以描述医护人员过敏性呼吸道疾病的负担和呼吸道菌群的改变，并总结了使用菌群干预改善呼吸道过敏的机制和临床研究现状，旨在为保护医护人员的呼吸道健康提供新方向。
