Wen Xin-Yue, Tang Xue-Yang, He Dan, Zhang Hai-Chao, Zhang Shui-Han, Zeng Hong-Liang
Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine Changsha 410013, China.
Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine Changsha 410013, China Center of Science and Technology Innovation, Hunan University of Chinese Medicine Changsha 410208, China.
Zhongguo Zhong Yao Za Zhi. 2021 Dec;46(24):6387-6394. doi: 10.19540/j.cnki.cjcmm.20210918.702.
Chronical hyperuricemia, a severe metabolic disease characterized by increased serum uric acid, urea nitrogen, and creatinine, has a positive correlation with the risks of gouty arthritis, diabetes, hypertension, and kidney damage. Abnormal purine metabolism and reduced uric acid excretion are the major causes of hyperuricemia, which, thus, points to a potential strategy of preventing from or delaying the progress of hyperuricemia-related diseases and its complications by effectively controlling the serum uric acid level. Increasing evidence has revealed that Chinese medicines alleviate hyperuricemia through regulating intestinal flora, which plays a pivotal role in regulating metabolites, including uric acid level. The disease treatment with traditional Chinese medicine is based on syndrome differentiation, and Chinese medicines often have multiple effects and a wide range of targets. In this review, we summarized the anti-hyperuricemia effects and mechanisms of active compounds in Chinese medicines, single Chinese medicinal herbs, and Chinese medicinal prescriptions in regulating the uric acid level via intestinal flora and metabolites, which will be helpful for further study and application of Chinese medicines in hyperuricemia treatment.
慢性高尿酸血症是一种以血清尿酸、尿素氮和肌酐升高为特征的严重代谢性疾病，与痛风性关节炎、糖尿病、高血压和肾损伤的风险呈正相关。嘌呤代谢异常和尿酸排泄减少是高尿酸血症的主要原因，因此，这表明通过有效控制血清尿酸水平来预防或延缓高尿酸血症相关疾病及其并发症进展的潜在策略。越来越多的证据表明，中药通过调节肠道菌群来缓解高尿酸血症，肠道菌群在调节包括尿酸水平在内的代谢产物方面起着关键作用。中医治病以辨证论治为基础，中药往往具有多种作用和广泛的靶点。在本综述中，我们总结了中药活性成分、单味中药和中药方剂通过肠道菌群和代谢产物调节尿酸水平的抗高尿酸血症作用及机制，这将有助于中药在高尿酸血症治疗中的进一步研究和应用。
