Yunnan University of Traditional Chinese Medicine, Kunming, China.
Front Cell Infect Microbiol. 2024 Aug 8;14:1341953. doi: 10.3389/fcimb.2024.1341953. eCollection 2024.
Gouty arthritis (GA), a metabolic and immunologic disease, primarily affects joints. Dysbiosis of intestinal flora is an important cause of GA. The metabolic disorders of intestinal flora leading to GA and immune disorders might play an important role in patients with hyperuricemia and established GA. However, the exact mechanisms, through which the dysbiosis of intestinal flora causes the development of GA, are not fully understood yet. Moreover, several therapies commonly used to treat GA might alter the intestinal flora, suggesting that modulation of the intestinal flora might help prevent or treat GA. Therefore, a better understanding of the changes in the intestinal flora of GA patients might facilitate the discovery of new diagnostic and therapeutic approaches. The current review article discusses the effects of intestinal flora dysbiosis on the pathogenesis of GA and the cross-regulatory effects between gut flora and drugs for treating GA. This article also highlights the modulatory effects of gut flora by traditional Chinese medicine (TCM) to lower uric acid levels and relieve joint pain as well as provides a summary and outlook, which might help guide future research efforts.
痛风性关节炎（GA）是一种代谢和免疫性疾病，主要影响关节。肠道菌群失调是 GA 的重要原因。肠道菌群代谢紊乱导致 GA 和免疫紊乱可能在高尿酸血症和已确诊 GA 患者中发挥重要作用。然而，肠道菌群失调导致 GA 发展的确切机制尚不完全清楚。此外，几种常用于治疗 GA 的疗法可能会改变肠道菌群，这表明调节肠道菌群可能有助于预防或治疗 GA。因此，更好地了解 GA 患者肠道菌群的变化可能有助于发现新的诊断和治疗方法。本文综述了肠道菌群失调对 GA 发病机制的影响，以及肠道菌群与治疗 GA 的药物之间的交叉调节作用。本文还强调了中药（TCM）调节肠道菌群以降低尿酸水平和缓解关节疼痛的作用，并提供了总结和展望，可能有助于指导未来的研究工作。
