Memory and Aging Center, Department of Neurology, University of California, San Francisco, California, USA.
Department of Pharmacology, CIBERSAM, University of the Basque Country (EHU/UPV) and Centro de Investigación Biomédica en Red de Salud Mental, Leioa, Spain.
Alzheimers Dement. 2022 Nov;18(11):2023-2035. doi: 10.1002/alz.12530. Epub 2022 Jan 7.
Physical activity (PA) is widely recommended for age-related brain health, yet its neurobiology is not well understood. Animal models indicate PA is synaptogenic. We examined the relationship between PA and synaptic integrity markers in older adults.
Four hundred four decedents from the Rush Memory and Aging Project completed annual actigraphy monitoring (Mean visits = 3.5±2.4) and post mortem evaluation. Brain tissue was analyzed for presynaptic proteins (synaptophysin, synaptotagmin-1, vesicle-associated membrane proteins, syntaxin, complexin-I, and complexin-II), and neuropathology. Models examined relationships between late-life PA (averaged across visits), and timing-specific PA (time to autopsy) with synaptic proteins.
Greater late-life PA associated with higher presynaptic protein levels (0.14 < β < 0.20), except complexin-II (β = 0.08). Relationships were independent of pathology but timing specific; participants who completed actigraphy within 2 years of brain tissue measurements showed largest PA-to-synaptic protein associations (0.32 < β < 0.38). Relationships between PA and presynaptic proteins were comparable across brain regions sampled.
PA associates with synaptic integrity in a regionally global, but time-linked nature in older adults.
身体活动（PA）被广泛推荐用于与年龄相关的大脑健康，但它的神经生物学机制尚不清楚。动物模型表明，PA 具有突触发生作用。我们研究了老年人的 PA 与突触完整性标志物之间的关系。
404 名来自拉什记忆和衰老项目的死者完成了年度活动监测（平均就诊次数为 3.5±2.4）和死后评估。对脑组织进行了突触前蛋白（突触小体蛋白、突触结合蛋白-1、囊泡相关膜蛋白、突触素、复合蛋白-I 和复合蛋白-II）和神经病理学分析。模型研究了晚年 PA（平均就诊次数）与时间特异性 PA（尸检时间）与突触蛋白之间的关系。
晚年 PA 与更高的突触前蛋白水平相关（0.14<β<0.20），但复合蛋白-II 除外（β=0.08）。这些关系独立于病理学，但具有时间特异性；在脑组织测量后 2 年内完成活动监测的参与者，PA 与突触蛋白的关联最大（0.32<β<0.38）。PA 与突触前蛋白之间的关系在取样的大脑区域中具有相似的特征。
PA 与老年人的突触完整性呈区域性、全球性但与时间相关的关联。
