Université Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale Paris-Saclay, 91401, Orsay, France.
Université de Lorraine, CNRS, L2CM, F-5400, Nancy, France.
Bioconjug Chem. 2022 Jan 19;33(1):24-52. doi: 10.1021/acs.bioconjchem.1c00503. Epub 2022 Jan 7.
Molecular imaging is a biomedical research discipline that has quickly emerged to afford the observation, characterization, monitoring, and quantification of biomarkers and biological processes in living organism. It covers a large array of imaging techniques, each of which provides anatomical, functional, or metabolic information. Multimodality, as the combination of two or more of these techniques, has proven to be one of the best options to boost their individual properties, hence offering unprecedented tools for human health. In this review, we will focus on the combination of positron emission tomography and fluorescence imaging from the specific perspective of the chemical synthesis of dual imaging agents. Based on a detailed analysis of the literature, this review aims at giving a comprehensive overview of the chemical strategies implemented to build adequate imaging tools considering radiohalogens and radiometals as positron emitters, fluorescent dyes mostly emitting in the NIR window and all types of targeting vectors.
分子影像学是一门快速发展的生物医学研究学科，它能够对生物体内的生物标志物和生物过程进行观察、描述、监测和定量分析。它涵盖了大量的成像技术，每种技术都提供解剖学、功能或代谢信息。多模态成像作为两种或多种技术的结合，已被证明是增强其各自特性的最佳选择之一，从而为人类健康提供了前所未有的工具。在这篇综述中，我们将从化学合成双模式成像探针的角度重点关注正电子发射断层扫描和荧光成像的结合。通过对文献的详细分析，本综述旨在全面概述构建适当成像工具所采用的化学策略，这些工具考虑了放射性卤素和放射性金属作为正电子发射体、主要在近红外窗口发射的荧光染料以及各种靶向载体。
