Idoko J A, Oyeyinka G O, Giassudin A S, Naida A
Department of Medicine, Ahmadu Bello University Hospital, Zaria, Nigeria.
J Infect. 1987 Jul;15(1):33-7. doi: 10.1016/s0163-4453(87)91376-4.
We investigated polymorphonuclear neutrophil (PMN) cell function and migration inhibition factor (MIF) in Nigerian patients with tropical pyomyositis (TP) and in healthy Nigerians as control subjects. The nitroblue tetrazolium (NBT) reduction test revealed that the ability of PMN to form formazan in patients was similar to that of the control subjects. This observation was taken to indicate that there may not be any metabolic defect in PMN of these patients. The MIF assay showed that the lymphocytes of the patients were significantly inefficient in responding in vitro to Staphylococcus aureus as compared with controls (S.D. 26 +/- 8 for patients, 53 +/- 10 for controls; P less than 0.01). This observation suggested that lymphocytes, particularly T-cells, of the patients were probably not primed adequately against S. aureus during the course of infection in vivo. The implications of these findings as they relate to tropical pyomyositis are discussed.
我们研究了尼日利亚热带脓性肌炎（TP）患者和作为对照的健康尼日利亚人的多形核中性粒细胞（PMN）功能及迁移抑制因子（MIF）。硝基四氮唑蓝（NBT）还原试验显示，患者PMN形成甲臜的能力与对照受试者相似。这一观察结果表明，这些患者的PMN可能不存在任何代谢缺陷。MIF测定表明，与对照组相比，患者的淋巴细胞在体外对金黄色葡萄球菌的反应明显低效（患者标准差为26±8，对照组为53±10；P<0.01）。这一观察结果表明，患者的淋巴细胞，尤其是T细胞，在体内感染过程中可能未充分针对金黄色葡萄球菌致敏。讨论了这些发现与热带脓性肌炎相关的意义。
