肠道微生物脂质组的结构和功能。
Structures and functions of the gut microbial lipidome.
机构信息
Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan; Division of Physiological Chemistry and Metabolism, Graduate School of Pharmaceutical Sciences, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan.
Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan; JSR Bioscience and Informatics R&D Center, JSR Corporation, 3-103-9 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-0821, Japan.
出版信息
Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Mar;1867(3):159110. doi: 10.1016/j.bbalip.2021.159110. Epub 2022 Jan 4.
Microbial lipids provide signals that are responsible for maintaining host health and controlling disease. The differences in the structures of microbial lipids have been shown to alter receptor selectivity and agonist/antagonist activity. Advanced lipidomics is an emerging field that helps to elucidate the complex bacterial lipid diversity. The use of cutting-edge technologies is expected to lead to the discovery of new functional metabolites involved in host homeostasis. This review aims to describe recent updates on functional lipid metabolites derived from gut microbiota, their structure-activity relationships, and advanced lipidomics technologies.
微生物脂质提供的信号负责维持宿主健康和控制疾病。微生物脂质结构的差异已被证明会改变受体选择性和激动剂/拮抗剂活性。先进的脂质组学是一个新兴领域，有助于阐明复杂的细菌脂质多样性。预计使用尖端技术将发现涉及宿主动态平衡的新功能代谢物。本综述旨在描述源自肠道微生物群的功能脂质代谢物的最新进展、它们的结构-活性关系以及先进的脂质组学技术。
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