Silva Carolina, Peixoto Francisco, Dias Isabel, Domingues Rosário, Viegas Carlos
Department of Veterinary Sciences, School of Agricultural and Veterinary Sciences (ECAV), University of Trás-os-Montes e Alto Douro (UTAD), Quinta de Prados, 5000-801 Vila Real, Portugal.
Animal and Veterinary Research Center (CECAV)-AL4AnimalS, University of Trás-os-Montes e Alto Douro (UTAD), 5000-801 Vila Real, Portugal.
Curr Med Chem. 2024 Oct 8. doi: 10.2174/0109298673323591240923051742.
INTRODUCTION/OBJECTIVE: Periodontal disease is a highly prevalent oral pathology in the human population, which has a significant local and systemic impact. Currently, multi-omics analyses, including lipidomics, are fundamental to obtaining an in-depth molecular understanding of the individual. Lipidomics is dedicated to the study of lipid species and their interactions in various health contexts. This specific multi-omics analysis is important for understanding the alteration of metabolism and signaling in disease, identifying biochemical markers, and potential therapeutic targets. This study aimed to carry out a systematic review of the existing scientific literature on lipidomics in periodontal disease and thus determine which molecules have already been analyzed and their potential in this specific disease.
This study followed the recommendations of the PRISMA 2020 methodology. The inclusion criteria used were articles published in indexed journals between 2000 and 2023, written in English, and establishing an exclusive relationship about lipidomics in human periodontal disease. The articles were searched in three different databases.
Considering the criteria defined, only six articles were selected and zed individually in detail. In four of the six studies, differences in the lipidome of individuals with periodontal disease were identified. Furthermore, phosphoethanolamine ceramide was found to have potential as a diagnostic biomarker. Finally, the therapeutic potential of a lipoxin A4 analogue was also identified.
These results reinforce the need for future research in this area so that the consequences of this disease on the lipidome can be identified.
引言/目的：牙周病是人类中一种高度普遍的口腔疾病，对局部和全身都有重大影响。目前，包括脂质组学在内的多组学分析对于深入了解个体的分子机制至关重要。脂质组学致力于研究脂质种类及其在各种健康背景下的相互作用。这种特定的多组学分析对于理解疾病中代谢和信号传导的改变、识别生化标志物以及潜在的治疗靶点非常重要。本研究旨在对牙周病脂质组学的现有科学文献进行系统综述，从而确定哪些分子已经被分析以及它们在这种特定疾病中的潜力。
本研究遵循PRISMA 2020方法学的建议。使用的纳入标准是2000年至2023年间发表在索引期刊上、用英文撰写且建立了关于人类牙周病脂质组学排他性关系的文章。在三个不同的数据库中搜索这些文章。
根据所定义的标准，仅筛选出六篇文章并分别进行详细分析。在六项研究中的四项中，发现了牙周病患者脂质组的差异。此外，磷酸乙醇胺神经酰胺被发现有作为诊断生物标志物的潜力。最后，还确定了脂氧素A4类似物的治疗潜力。
这些结果强化了该领域未来研究的必要性，以便能够确定这种疾病对脂质组的影响。
