Department of Physics, PSGR Krishnammal College for Women, Peelamedu, Coimbatore, Tamilnadu, India.
Associate Professor and Head, Department of Physics, PSGR Krishnammal College for Women, Peelamedu, Coimbatore, Tamilnadu, India.
J Trace Elem Med Biol. 2022 Mar;70:126916. doi: 10.1016/j.jtemb.2021.126916. Epub 2021 Dec 22.
This contribution of work describes a new strategy for manufacturing cobalt oxide nanoparticles and the results assured that, its efficiency was increased by adding Fe ions. The anticancer drugs usually have a limited medical value owing to their nonspecific cytotoxicity. It has been proven that by using the nanosystems to deliver tablets to tumour cells reduces the toxic quality. Because of these qualities, nanoparticles can be used as a stronger rival for potent cancer treatment.
This study investigated the cytotoxicity of iron doped cobalt oxide nanoparticles through trypan blue exclusion method.
The newly generated Fe doped CoO nanoparticles had proved its biocompatibility from the report of reduced toxicity below 200 μg/mL on malignant cell lines.
The observed findings may encourage the development of anticancer drugs based on the inorganic particles, especially Fe doped CoO nanoparticles, that could be serve as an excellent framework for the drug delivery and provide a new perspective for interpreting and targeting various therapeutic methodologies to tumours.
本工作贡献描述了一种制造氧化钴纳米粒子的新策略，并证实通过添加 Fe 离子可以提高其效率。抗癌药物通常由于其非特异性细胞毒性而具有有限的医学价值。已经证明，使用纳米系统将片剂递送到肿瘤细胞可以降低毒性。由于这些特性，纳米颗粒可用作更有效的癌症治疗有力竞争者。
本研究通过台盼蓝排除法研究了铁掺杂氧化钴纳米颗粒的细胞毒性。
新生成的 Fe 掺杂 CoO 纳米颗粒的毒性低于 200μg/mL，在恶性细胞系中已被证明具有生物相容性。
观察到的结果可能会鼓励基于无机颗粒的抗癌药物的开发，特别是 Fe 掺杂 CoO 纳米颗粒，它们可以作为药物输送的理想框架，并为肿瘤的各种治疗方法的解释和靶向提供新的视角。
