Department of Orthopedics, The first affiliated Hospital of Army Medical University, Army Medical University, Gaotanyan Street No. 30, Chongqing, 400038, China.
Battalion of Basic Medical Sciences, Army Medical University, Chongqing, 400038, China.
Lipids Health Dis. 2022 Jan 7;21(1):5. doi: 10.1186/s12944-021-01615-5.
Recent advances in society have resulted in the emergence of both hyperlipidemia and obesity as life-threatening conditions in people with implications for various types of diseases, such as cardiovascular diseases and cancer. This is further complicated by a global rise in the aging population, especially menopausal women, who mostly suffer from overweight and bone loss simultaneously. Interestingly, clinical observations in these women suggest that osteoarthritis may be linked to a higher body mass index (BMI), which has led many to believe that there may be some degree of bone dysfunction associated with conditions such as obesity. It is also common practice in many outpatient settings to encourage patients to control their BMI and lose weight in an attempt to mitigate mechanical stress and thus reduce bone pain and joint dysfunction. Together, studies show that bone is not only a mechanical organ but also a critical component of metabolism, and various endocrine functions, such as calcium metabolism. Numerous studies have demonstrated a relationship between metabolic dysfunction in bone and abnormal lipid metabolism. Previous studies have also regarded obesity as a metabolic disorder. However, the relationship between lipid metabolism and bone metabolism has not been fully elucidated. In this narrative review, the data describing the close relationship between bone and lipid metabolism was summarized and the impact on both the normal physiology and pathophysiology of these tissues was discussed at both the molecular and cellular levels.
近年来，社会的进步导致高血脂和肥胖症成为威胁人类生命的两种疾病，这对各种疾病都有影响，如心血管疾病和癌症。全球人口老龄化的加剧使情况更加复杂，尤其是绝经后妇女，她们大多同时超重和骨质疏松。有趣的是，对这些女性的临床观察表明，骨关节炎可能与更高的体重指数（BMI）有关，这使得许多人相信肥胖等疾病可能与一定程度的骨功能障碍有关。在许多门诊环境中，鼓励患者控制 BMI 并减肥以减轻机械压力，从而减轻骨痛和关节功能障碍也是一种常见做法。总之，研究表明，骨骼不仅是一个机械器官，也是新陈代谢和各种内分泌功能（如钙代谢）的关键组成部分。大量研究表明，骨骼代谢功能障碍与异常脂质代谢之间存在关联。以前的研究也将肥胖视为一种代谢紊乱。然而，脂质代谢和骨代谢之间的关系尚未完全阐明。在这篇叙述性综述中，总结了描述骨和脂质代谢之间密切关系的数据，并在分子和细胞水平上讨论了这对这些组织的正常生理学和病理生理学的影响。
