丁丙诺啡：阿片类药物引起呼吸抑制的治疗药物和原因。
Buprenorphine: a treatment and cause of opioid-induced respiratory depression.
机构信息
Department of Anesthesiology, Anesthesia & Pain Research Unit, Leiden University Medical Center, Leiden, the Netherlands.
Department of Anesthesiology, Anesthesia & Pain Research Unit, Leiden University Medical Center, Leiden, the Netherlands.
出版信息
Br J Anaesth. 2022 Mar;128(3):402-404. doi: 10.1016/j.bja.2021.12.001. Epub 2022 Jan 5.
PMID:34996591
Abstract
Buprenorphine is a partial agonist at the mu opioid receptor. Due to its relatively low maximum effect on respiratory depression it is considered by some to be a safe opioid. But it can produce serious respiratory depression, particularly when combined with sedatives such as benzodiazepines.
摘要
丁丙诺啡是一种μ阿片受体部分激动剂。由于其对呼吸抑制的最大效应相对较低，因此一些人认为它是一种安全的阿片类药物。但它可引起严重的呼吸抑制，特别是与苯二氮䓬类镇静剂合用时。
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