Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.
Department of Respiratory Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Japan.
Thorax. 2022 May;77(5):508-510. doi: 10.1136/thoraxjnl-2021-217693. Epub 2022 Jan 7.
A subset of patients with hypersensitivity pneumonitis (HP) develop lung fibrosis that is clinically similar to idiopathic pulmonary fibrosis (IPF). To address the aetiological determinants of fibrotic HP, we investigated whether the common IPF genetic risk variants were also relevant in study subjects with fibrotic HP. Our findings indicate that common genetic variants in , , and were significantly associated with fibrotic HP. These findings provide support for a shared etiology and pathogenesis between fibrotic HP and IPF.
一部分过敏性肺炎(HP)患者会发展为肺纤维化,其临床表现与特发性肺纤维化(IPF)相似。为了明确导致纤维化性 HP 的病因学决定因素,我们研究了纤维化性 HP 患者是否存在常见的 IPF 遗传风险变异。研究结果表明, 、 、 和 中的常见遗传变异与纤维化性 HP 显著相关。这些发现为纤维化性 HP 和 IPF 具有共同的病因和发病机制提供了支持。