肿瘤学中基于抗体疗法的进展。
Advances in antibody-based therapy in oncology.
作者信息
Zinn Sacha, Vazquez-Lombardi Rodrigo, Zimmermann Carsten, Sapra Puja, Jermutus Lutz, Christ Daniel
机构信息
Garvan Institute of Medical Research, Sydney, New South Wales, Australia.
Faculty of Medicine, The University of New South Wales, St Vincent's Clinical School, Darlinghurst, Sydney, New South Wales, Australia.
出版信息
Nat Cancer. 2023 Feb;4(2):165-180. doi: 10.1038/s43018-023-00516-z. Epub 2023 Feb 20.
Monoclonal antibodies are a growing class of targeted cancer therapeutics, characterized by exquisite specificity, long serum half-life, high affinity and immune effector functions. In this review, we outline key advances in the field with a particular focus on recent and emerging classes of engineered antibody therapeutic candidates, discuss molecular structure and mechanisms of action and provide updates on clinical development and practice.
单克隆抗体是一类不断发展的靶向癌症治疗药物，其特点是具有极高的特异性、较长的血清半衰期、高亲和力和免疫效应功能。在本综述中，我们概述了该领域的关键进展，特别关注工程化抗体治疗候选药物的最新和新兴类别，讨论了分子结构和作用机制，并提供了临床开发和实践的最新情况。
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