Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
J Mol Med (Berl). 2022 Apr;100(4):485-498. doi: 10.1007/s00109-021-02172-1. Epub 2022 Jan 8.
Diabetes is primarily characterized by hyperglycemia, and its high incidence is often very costly to patients, their families, and national economies. Unsurprisingly, the number and function of endothelial progenitor cells (EPCs) decrease in patients resulting in diabetic wound non-healing. As precursors of endothelial cells (ECs), these cells were discovered in 1997 and found to play an essential role in wound healing. Their function, number, and role in wound healing has been widely investigated. Hitherto, a lot of complex molecular mechanisms have been discovered. In this review, we summarize the mechanisms of how hyperglycemia affects the function and number of EPCs and how the affected cells impact wound healing. We aim to provide a complete summary of the relationship between diabetic hyperglycosemia, EPCs, and wound healing, as well as a better comprehensive platform for subsequent related research.
糖尿病的主要特征是高血糖，其高发率常常给患者、患者家庭和国家经济带来沉重负担。毫不奇怪，糖尿病患者的内皮祖细胞 (EPCs) 数量和功能会减少，导致糖尿病伤口难以愈合。作为内皮细胞 (ECs) 的前体细胞，这些细胞于 1997 年被发现，在伤口愈合中发挥着重要作用。它们的功能、数量及其在伤口愈合中的作用已被广泛研究。迄今为止，已经发现了许多复杂的分子机制。在这篇综述中，我们总结了高血糖如何影响 EPCs 的功能和数量，以及受影响的细胞如何影响伤口愈合的机制。我们旨在为糖尿病高血糖、EPCs 和伤口愈合之间的关系提供一个完整的总结，并为后续的相关研究提供一个更好的综合平台。
