Hunan Key Laboratory of Non Resolving Inflammation and Cancer, The Third Xiangya Hospital of Central South University, Changsha, China.
Hunan Aerospace Hospital, Changsha, China.
Hematol Oncol. 2023 Apr;41(2):285-290. doi: 10.1002/hon.2962. Epub 2022 Jan 20.
TAFRO syndrome is a peculiar and rare type of multi-centric Castleman's disease which contained a series of symptoms such as thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), and organomegaly (O). Here we provide a case of TAFRO syndrome with the manifestation of fatigue, abdominal distension, and low fever at primary diagnosis, characterized by multiple lymphadenopathy of superficial mediastinal and retroperitoneal lymph nodes, and it was finally confirmed by lymph node biopsy. The patient recovered speedy after receiving CHOP chemotherapy. In this case report, the patient has a history of dust-exposure and hepatitis B virus infection, which may be potentially related to the disease. In addition, this case suggests the importance of pathological biopsy of complete lymph nodes in diagnostic process.
TAFRO 综合征是一种独特而罕见的多中心 Castleman 病，具有一系列症状，如血小板减少症（T）、全身浮肿（A）、发热（F）、网状纤维纤维化（R）和器官肿大（O）。在这里，我们提供了一例 TAFRO 综合征的病例，其初诊表现为疲劳、腹胀和低热，特征为纵隔和腹膜后浅表淋巴结多发性淋巴结病，最终通过淋巴结活检得到确诊。该患者接受 CHOP 化疗后迅速康复。在这个病例报告中，患者有粉尘暴露和乙型肝炎病毒感染史，这可能与疾病有关。此外，该病例提示了在诊断过程中对完整淋巴结进行病理活检的重要性。
