Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Japan.
Department of Pathology, Kurume University School of Medicine, Japan.
Intern Med. 2022 Oct 1;61(19):2967-2972. doi: 10.2169/internalmedicine.9160-21. Epub 2022 Feb 26.
Thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) syndrome is a systemic inflammatory disorder characterized by the above-mentioned symptoms. Because of the similarity in phenotypes between TAFRO syndrome and decompensated liver cirrhosis, an accurate diagnosis is often difficult. We herein report a 62-year-old Japanese patient with TAFRO syndrome who was misdiagnosed with intractable ascites associated with liver cirrhosis. Improvement of symptoms after treatment with prednisolone was associated with interleukin-6 rather than C-reactive protein. The pathogenesis of TAFRO syndrome, which has similar clinical manifestations to liver cirrhosis, remains unclear, and our findings may help elucidate the concept of this condition.
血小板减少症、全身性水肿、发热、网状纤维纤维化和器官肿大（TAFRO）综合征是一种以上述症状为特征的系统性炎症性疾病。由于 TAFRO 综合征和失代偿性肝硬化在表型上的相似性，准确的诊断往往很困难。本文报告了一例 62 岁的日本 TAFRO 综合征患者，该患者被误诊为肝硬化伴难治性腹水。泼尼松龙治疗后症状改善与白细胞介素-6而非 C 反应蛋白相关。TAFRO 综合征的发病机制与肝硬化具有相似的临床表现，但尚不清楚，我们的发现可能有助于阐明这种情况的概念。
