G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Division of Russian Academy of Sciences, Vladivostok, Russia.
Far Eastern Federal University, Vladivostok, Russia.
Bull Exp Biol Med. 2022 Jan;172(3):292-296. doi: 10.1007/s10517-022-05379-5. Epub 2022 Jan 8.
The neuroprotective effects of the course therapy with Histochrome in Wistar rats with modeled arterial hypertension were studied by using magnetic resonance imaging (MRI) in diffusion-weighted mode. The behavioral status of the animals was assessed using the open-field test. MRI analysis revealed more pronounced increase in the signaling characteristics of the brain tissue in hypertensive rats in comparison with the control (intact) animals. It was caused by excessive accumulation of fluid in the intra- and extracellular spaces of the brain tissue, which is associated with hypervolemia induced by the multifactorial cardiovasorenal model of hypertension. After a course of Histochrome injections to hypertensive rats, the cerebral microcirculation disorders were leveled, while the behavioral status was characterized by shortened latency of the visit to the center of the open field by 20% and improvement of cognitive activity (by 1.6 times) and the exploratory component (by 30%).
采用磁共振弥散加权成像（MRI）研究了组织铬在伴有动脉高血压的 Wistar 大鼠模型中的疗程治疗的神经保护作用。通过旷场试验评估动物的行为状态。MRI 分析显示，与对照组（完整）动物相比，高血压大鼠的脑组织信号特征增加更为明显。这是由于脑组织的细胞内和细胞外空间中液体的过度积累所致，这与高血压的多因素心血管肾模型引起的血容量过多有关。在给高血压大鼠注射组织铬疗程后，大脑微循环障碍得到了平衡，而行为状态的特征是进入旷场中心的潜伏期缩短了 20%，认知活动（提高 1.6 倍）和探索成分（提高 30%）得到了改善。
