Seo Dae Yun, McGregor Robin A, Noh Su Jin, Choi Seung Jun, Mishchenko Natalia P, Fedoreyev Sergey A, Stonik Valentin A, Han Jin
National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Bokji-ro 75, Busanjin, Busan 633-165, Korea.
Division of Sports and Health Science, Kyungsung University, 309 Suyoung-ro, Nam-gu, Busan 608-736, Korea.
Mar Drugs. 2015 Sep 8;13(9):5722-31. doi: 10.3390/md13095722.
Echinochrome A (Echi A) improves mitochondrial function in the heart; however, its effects on skeletal muscle are still unclear. We hypothesized that Echi A administration during short-term exercise may improve exercise capacity. Twenty-four male Sprague-Dawley rats were randomly divided into the following groups: control group (CG), Echi A-treated group (EG), aerobic exercise group (AG), and aerobic exercise treated with Echi A group (AEG) (n = 6 per group). Echi A was administered intra-peritoneally (0.1 mg/kg of Echi A in 300 µL phosphate-buffered saline) daily 30 min before each exercise training. The AG and AEG groups performed treadmill running (20 m/min, 60 min/day) five days/week for two weeks. The exercise capacity was significantly higher in the AG and AEG groups compared to other groups. Interestingly, the exercise capacity increased more effectively in the AEG group. The body weight in the EG tended to be slightly lower than that in the other groups. There were no significant changes in the plasma lipids among the groups. However, the gastrocnemius muscle mitochondria content was greater in the EG and AEG groups. These findings show that Echi A administration after short-term endurance training enhances exercise capacity, which was associated with an increase in skeletal muscle mitochondrial content.
海胆色素A（Echi A）可改善心脏的线粒体功能；然而，其对骨骼肌的影响仍不明确。我们推测在短期运动期间给予Echi A可能会提高运动能力。将24只雄性Sprague-Dawley大鼠随机分为以下几组：对照组（CG）、Echi A处理组（EG）、有氧运动组（AG）和Echi A处理的有氧运动组（AEG）（每组n = 6）。在每次运动训练前30分钟，每天腹腔注射Echi A（0.1 mg/kg的Echi A溶于300 μL磷酸盐缓冲盐水中）。AG组和AEG组每周五天、持续两周进行跑步机跑步（20米/分钟，每天60分钟）。与其他组相比，AG组和AEG组的运动能力显著更高。有趣的是，AEG组的运动能力提高得更有效。EG组的体重往往略低于其他组。各组之间的血脂没有显著变化。然而，EG组和AEG组的腓肠肌线粒体含量更高。这些发现表明，短期耐力训练后给予Echi A可提高运动能力，这与骨骼肌线粒体含量增加有关。
