Nanoprecipitation technology to prepare carrier systems of interest in pharmaceutics: An overview of patenting.

Nanoprecipitation is a practical method to prepare carriers at the nanometric scale, which attracts attention in pharmaceutics because of its low cost, easy setup, the versatility of the starting materials, possibility to obtain different kinds of carriers, and minimal environmental impact. Since 1986, this technique has been extensively employed in research; therefore, this paper focuses on state of art regarding inventions wherein it is employed. To this end, 133 nanoprecipitation-based patent families are identified in the PatSnap® platform, which allows identifying general trends. Afterwards, a sample of 40 patent families reported as granted (21 families) or patent applications (19 families) during the last decade are studied in depth to establish the research tendencies. Undoubtedly, Chinese universities are positioned as leaders in this field, and cancer treatments are the more claimed use followed far behind for developments targeting neurodegenerative and diabetes diseases. New proposals on targeted and stimuli response particles are also claimed, and development of polymers, prodrugs, and improvements to the technique such as the flash-nanoprecipitation, use of microfluidics, or design of green process are relevant. Interestingly, nanoprecipitation-related patent families have significantly increased during the last decade, being the 71% of the total, which makes alluring the perspectives about its industrial harnessing.