Department of Molecular and Human Genetics, Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
Mamm Genome. 2022 Mar;33(1):91-99. doi: 10.1007/s00335-021-09922-z. Epub 2022 Jan 9.
Rhesus macaques (Macaca mulatta) are among the most extensively studied of nonhuman primates. This species has been the subject of many investigations concerning basic primate biology and behavior, including studies of social organization, developmental psychology, physiology, endocrinology, and neurodevelopment. Rhesus macaques are also critically important as a nonhuman primate model of human health and disease, including use in studies of infectious diseases, metabolic diseases, aging, and drug or alcohol abuse. Current research addressing fundamental biological and/or applied biomedical questions benefits from various genetic and genomic analyses. As a result, the genome of rhesus macaques has been the subject of more study than most nonhuman primates. This paper briefly discusses a number of information resources that can provide interested researchers with access to genetic and genomic data describing the content of the rhesus macaque genome, available information regarding genetic variation within the species, results from studies of gene expression, and other aspects of genomic analysis. Specific online databases are discussed, including the US National Center for Biotechnology Information, the University of California Santa Cruz genome browser, Ensembl genome browser, the Macaque Genotype and Phenotype database (mGAP), Rhesusbase, and others.
恒河猴（Macaca mulatta）是最广泛研究的非人类灵长类动物之一。该物种已经成为许多关于基本灵长类生物学和行为的研究主题，包括社会组织、发展心理学、生理学、内分泌学和神经发育的研究。恒河猴作为人类健康和疾病的非人类灵长类模型也非常重要，包括在传染病、代谢疾病、衰老和药物或酒精滥用研究中的应用。当前解决基本生物学和/或应用生物医学问题的研究受益于各种遗传和基因组分析。因此，恒河猴的基因组比大多数非人类灵长类动物受到更多的研究。本文简要讨论了一些信息资源，这些资源可以为有兴趣的研究人员提供访问描述恒河猴基因组内容的遗传和基因组数据的途径，有关该物种内遗传变异的可用信息，基因表达研究的结果以及基因组分析的其他方面。讨论了特定的在线数据库，包括美国国家生物技术信息中心、加利福尼亚大学圣克鲁斯基因组浏览器、Ensembl 基因组浏览器、猕猴基因型和表型数据库（mGAP）、Rhesusbase 等。
