帕金森病患者摄入咖啡后咖啡因对腺苷A受体的占据情况
Adenosine A Receptor Occupancy by Caffeine After Coffee Intake in Parkinson's Disease.
作者信息
Ishibashi Kenji, Miura Yoshiharu, Wagatsuma Kei, Toyohara Jun, Ishiwata Kiichi, Ishii Kenji
机构信息
Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Department of Neurology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
出版信息
Mov Disord. 2022 Apr;37(4):853-857. doi: 10.1002/mds.28897. Epub 2022 Jan 9.
BACKGROUND
Coffee intake can decrease the risk for Parkinson's disease (PD). Its beneficial effects are allegedly mediated by caffeine through adenosine A receptor (A R) antagonist action.
OBJECTIVE
We aimed to calculate occupancy rates of striatal A Rs by caffeine after coffee intake in PD.
METHODS
Five patients with PD underwent C-preladenant positron emission tomography scanning at baseline and after intake of coffee containing 129.5 mg (n = 3) or 259 mg (n = 2) of caffeine. Concurrently, serum caffeine levels were measured.
RESULTS
The mean serum caffeine level (μg/mL) was 0.374 at baseline and increased to 4.48 and 8.92 by 129.5 and 259 mg of caffeine, respectively. The mean occupancy rates of striatal A Rs by 129.5 and 259 mg of caffeine were 54.2% and 65.1%, respectively.
CONCLUSIONS
A sufficient A R occupancy can be obtained by drinking a cup of coffee, which is equivalent to approximately 100 mg of caffeine. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
背景
摄入咖啡可降低患帕金森病（PD）的风险。据称其有益作用是由咖啡因通过腺苷A受体（AR）拮抗作用介导的。
目的
我们旨在计算帕金森病患者摄入咖啡后咖啡因对纹状体AR的占有率。
方法
5例帕金森病患者在基线时以及摄入含129.5 mg（n = 3）或259 mg（n = 2）咖啡因的咖啡后，接受11C-普拉克索正电子发射断层扫描。同时，测量血清咖啡因水平。
结果
基线时血清咖啡因平均水平（μg/mL）为0.374，摄入129.5 mg和259 mg咖啡因后分别升至4.48和8.92。129.5 mg和259 mg咖啡因对纹状体AR的平均占有率分别为54.2%和65.1%。
结论
喝一杯咖啡（约相当于100 mg咖啡因）即可获得足够的AR占有率。© 2022作者。《运动障碍》由Wiley Periodicals LLC代表国际帕金森和运动障碍协会出版。
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