Lee Lai Kuan, Mhd Rodzi Nur Anis Raihana
Food Technology Program, School of Industrial Technology, Universiti Sains Malaysia, Gelugor 11800, Pulau Pinang, Malaysia.
Antioxidants (Basel). 2022 Aug 16;11(8):1587. doi: 10.3390/antiox11081587.
Caffeine is one of the predominant dietary components and psychostimulants present in coffee, a widely appreciated beverage. Corroborating epidemiological and laboratory evidence have suggested an inverse association between the dietary intakes of coffee and the risk of Parkinson's Disease (PD). Growing attention has been paid to the impact of coffee consumption and genetic susceptibility to PD pathogenesis. Coffee is believed to play prominent roles in mediating the gene makeup and influencing the onset and progression of PD. The current review documents a current discovery of the coffee × gene interaction for the protective management of PD. The evidence underlying its potent impacts on the adenosine receptors (AR), estrogen receptors (ESR), heme oxygenase (HO), toxicant responsive genes, nitric oxide synthase (NOS), cytochrome oxidase (Cox), familial parkinsonism genetic susceptibility loci, bone marrow stromal cell antigen 1 (BST1), glutamate receptor gene and apolipoprotein E (APOE) genotype expressions is outlined. Furthermore, the neuroprotective mechanisms of coffee for the amelioration of PD are elucidated.
咖啡因是咖啡中主要的膳食成分和精神兴奋剂之一，咖啡是一种广受欢迎的饮品。越来越多的确凿流行病学和实验室证据表明，咖啡的膳食摄入量与帕金森病（PD）风险之间呈负相关。咖啡消费对PD发病机制的影响以及遗传易感性越来越受到关注。咖啡被认为在介导基因组成和影响PD的发病及进展方面发挥着重要作用。本综述记录了目前关于咖啡×基因相互作用对PD进行保护性管理的发现。概述了其对腺苷受体（AR）、雌激素受体（ESR）、血红素加氧酶（HO）、毒物反应基因、一氧化氮合酶（NOS）、细胞色素氧化酶（Cox）、家族性帕金森病遗传易感性位点、骨髓基质细胞抗原1（BST1）、谷氨酸受体基因和载脂蛋白E（APOE）基因型表达产生强大影响的相关证据。此外，还阐明了咖啡改善PD的神经保护机制。
