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刮片细胞学检查在肿瘤性病变评估中的诊断效用与准确性

Diagnostic Utility and Accuracy of Scrape Cytology in Evaluation of Neoplastic Lesions.

作者信息

Sharma Tanya, Singhal Sheetal, Kapoor Neelkamal

机构信息

Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.

出版信息

J Cytol. 2021 Oct-Dec;38(4):186-190. doi: 10.4103/JOC.JOC_211_20. Epub 2021 Nov 15.

Abstract

BACKGROUND

Frozen section, intraoperative fine needle aspiration cytology (FNAC) and imprint cytology have been used traditionally by the surgical pathology laboratories for rapid intraoperative diagnosis of tumors. Scrape cytology is a modification of imprint cytology that involves lightly scraping or brushing cells from freshly cut surface of the surgically removed tumor specimens. The present study was carried out to evaluate the utility of scrape cytology in diagnostic evaluation of tumors.

MATERIAL AND METHODS

A prospective study was carried out at a tertiary care teaching hospital in Central India. A total of 50 consecutively received specimens in the Department of Pathology and Laboratory Medicine with clinical or radiological suspicion of neoplasia were included in the study. Scrape smears were prepared from freshly cut surface of tumor specimens received unfixed or in 10% formalin.

RESULTS

Overall, the scrape cytology diagnosis was concordant with final histopathological diagnosis in 48 out of 50 cases with a diagnostic accuracy of 96%. The sensitivity was 90.9% (CI-58.72% to 99.77%) and specificity was 97.4%(CI-86.52% to 99.94%). Positive predictive value and negative predictive value were 90.91% and 97.44%, respectively.

CONCLUSION

Scrape cytology is a cost-effective and reasonably accurate cytodiagnostic technique for rapid tumor diagnosis. Scrape cytology can be a useful supplementary tool to frozen section, and may be applied for rapid diagnosis where frozen section technique is not available. The material and knowledge obtained from scrape cytology of routinely received histopathological specimens can be utilized as a teaching material and may help unveil diagnostic cytopathological features of infrequent cytologically encountered lesions.

摘要

背景

冰冻切片、术中细针穿刺细胞学检查(FNAC)和印片细胞学检查一直被外科病理实验室用于肿瘤的术中快速诊断。刮片细胞学是印片细胞学的一种改良方法,它涉及从手术切除的肿瘤标本的新鲜切面轻轻刮取或刷取细胞。本研究旨在评估刮片细胞学在肿瘤诊断评估中的效用。

材料与方法

在印度中部的一家三级护理教学医院进行了一项前瞻性研究。病理学和检验医学科共纳入了50例临床或影像学怀疑为肿瘤的连续送检标本。从不固定或用10%福尔马林固定的肿瘤标本新鲜切面上制备刮片涂片。

结果

总体而言,50例中有48例刮片细胞学诊断与最终组织病理学诊断一致,诊断准确率为96%。敏感性为90.9%(CI - 58.72%至99.77%),特异性为97.4%(CI - 86.52%至99.94%)。阳性预测值和阴性预测值分别为90.91%和97.44%。

结论

刮片细胞学是一种用于快速肿瘤诊断的经济高效且准确性合理的细胞诊断技术。刮片细胞学可以成为冰冻切片的有用辅助工具,并且可应用于无法使用冰冻切片技术的快速诊断。从常规接收的组织病理学标本的刮片细胞学中获得的材料和知识可作为教学材料,并可能有助于揭示罕见细胞学病变的诊断细胞病理学特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/630e/8670451/80965bcca635/JCytol-38-186-g001.jpg

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