Jaiswal Yashika P, Gadkari Rasika U
Department of Pathology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India.
J Cytol. 2020 Jul-Sep;37(3):126-130. doi: 10.4103/JOC.JOC_94_19. Epub 2020 Jun 30.
Intraoperative pathological assessment provides valuable information in a patient's diagnosis and management. Touch imprint/crush cytology is simple, rapid, and cost-effective. Also, imprint smears give excellent cytomorphology.
To assess the utility and feasibility of intraoperative cytology technique as a rapid and reliable method for diagnosis and to compare sensitivity, specificity and diagnostic accuracy with histopathology.
Cytology smears were collected intraoperatively from 52 cases of suspected/proven malignancy. From tumors, surgical margins, lymph nodes; crush, imprint, and scrape smears were prepared. Smears were taken from specimens before formalin fixation and stained with rapid ultrafast Papanicolaou stain. The slides were compared with the histopathology report which is the gold standard.
Sensitivity, specificity, and diagnostic accuracy were used for statistical analysis.
Intraoperative cytology report could be given in time for the surgeon to modify margins of resection and the extent of lymph node dissection. It helps the surgeon to modify surgery. The diagnostic test evaluation showed satisfactory results.
Intraoperative imprint/crush cytology is a simple, inexpensive, rapid, accurate cytodiagnostic technique in the diagnosis of cancer where frozen section facilities are not available. It can also be used to assess the clearance of surgical margins.
术中病理评估为患者的诊断和治疗提供了有价值的信息。触摸印片/压碎细胞学检查简单、快速且具有成本效益。此外，印片涂片能提供出色的细胞形态学特征。
评估术中细胞学技术作为一种快速可靠的诊断方法的实用性和可行性，并与组织病理学比较其敏感性、特异性和诊断准确性。
术中从52例疑似/确诊恶性肿瘤病例中采集细胞学涂片。从肿瘤、手术切缘、淋巴结处制备压碎、印片和刮片涂片。在标本用福尔马林固定前取材涂片，并用快速超巴氏染色法染色。将玻片与作为金标准的组织病理学报告进行比较。
采用敏感性、特异性和诊断准确性进行统计学分析。
术中细胞学报告能及时提供给外科医生，以便其修改切除边缘和淋巴结清扫范围。它有助于外科医生调整手术方案。诊断试验评估显示结果令人满意。
术中印片/压碎细胞学检查是一种简单、廉价、快速、准确的细胞诊断技术，适用于无法进行冰冻切片检查的癌症诊断。它还可用于评估手术切缘的清除情况。
