Bose Mousumi, Hagerty Jason, Boes Jason, Kim Chang-Soo, Stoecker William, Nam Paul
Department of Chemistry, Missouri University of Science and Technology, Rolla, MO 65409 USA.
Department of Electrical and Computer Engineering, Missouri University of Science and Technology, Rolla, MO 65409 USA.
IEEE Sens J. 2021 Oct 1;21(19):21494-21502. doi: 10.1109/jsen.2021.3105655. Epub 2021 Aug 18.
Optical oxygen sensors based on photoluminescence quenching have gained increasing attention as a superior method for continuous monitoring of oxygen in a growing number of applications. A simple and low-cost fabrication technique was developed to produce sensor arrays capable of two-dimensional oxygen tension measurement. Sensor patches were printed on polyvinylidene chloride film using an oxygen-sensitive ink cocktail, prepared by immobilizing Pt(II) mesotetra(pentafluorophenyl)porphine (PtTFPP) in monodispersed polystyrene microparticles. The dispersion media of the ink cocktail, high molecular weight polyvinyl pyrrolidone suspended in 50% ethanol (v/v in water), allowed adhesion promotion and compatibility with most common polymeric substrates. Ink phosphorescence intensity was found to vary primarily with fluorophore concentration and to a lesser extent with polystyrene particle size. The sensor performance was investigated as a function of oxygen concentrations employing two different techniques: a multi-frequency phase fluorometer and smart phone-based image acquisition. The printed sensor patch showed fast and repetitive response over 0-21% oxygen concentrations with high linearity (with R >0.99) in a Stern-Volmer plot, and sensitivity of I/I >1.55. The optical sensor response on a surface was investigated further using two-dimensional images which were captured and analyzed under different oxygen environment. Printed sensor patch along with imaging read-out technique make an ideal platform for early detection of surface wounds associated with tissue oxygen.
基于光致发光猝灭的光学氧传感器作为一种用于在越来越多应用中连续监测氧气的优越方法，已受到越来越多的关注。开发了一种简单且低成本的制造技术来生产能够进行二维氧张力测量的传感器阵列。使用一种对氧敏感的油墨混合物在聚偏二氯乙烯薄膜上印刷传感器贴片，该油墨混合物是通过将中四（五氟苯基）卟啉铂（PtTFPP）固定在单分散聚苯乙烯微粒中制备而成。该油墨混合物的分散介质，即悬浮在50%乙醇（体积比，相对于水）中的高分子量聚乙烯吡咯烷酮，有助于促进附着力并与大多数常见聚合物基材兼容。发现油墨的磷光强度主要随荧光团浓度变化，在较小程度上随聚苯乙烯颗粒大小变化。采用两种不同技术研究了传感器性能随氧浓度的变化：多频相位荧光计和基于智能手机的图像采集。印刷的传感器贴片在0 - 21%氧浓度范围内显示出快速且重复的响应，在斯特恩 - 沃尔默图中具有高线性（R>0.99），并且I/I的灵敏度>1.55。使用在不同氧环境下捕获和分析的二维图像进一步研究了表面上的光学传感器响应。印刷的传感器贴片连同成像读出技术构成了一个用于早期检测与组织氧相关的表面伤口的理想平台。
