B细胞刺激因子1（白细胞介素4）足以使凝集素刺激的细胞毒性T淋巴细胞前体增殖和分化。
B cell stimulatory factor 1 (interleukin 4) is sufficient for the proliferation and differentiation of lectin-stimulated cytolytic T lymphocyte precursors.
作者信息
Pfeifer J D, McKenzie D T, Swain S L, Dutton R W
机构信息
Department of Biology, University of California, San Diego, La Jolla 92093.
出版信息
J Exp Med. 1987 Nov 1;166(5):1464-70. doi: 10.1084/jem.166.5.1464.
Abstract
In this report, we demonstrate that IL-4 is sufficient to stimulate both the proliferation and differentiation of Lyt-2+, Ia- splenic CTL precursors stimulated with the mitogenic lectin Con A. The response to IL-4 and Con A was not dependent on a putative endogenous production of IL-2 within the cultures, as demonstrated by an absence of an inhibitory effect by an anti-IL-2-R blocking mAb. Our results indicate that IL-2 and IL-4 can support an equivalent proliferative response by lectin-stimulated Lyt-2+ T lymphocytes, while IL-4 is more efficacious in stimulating their differentiation into mature cytolytically active cells.
摘要
在本报告中，我们证明白细胞介素-4（IL-4）足以刺激用促有丝分裂凝集素伴刀豆球蛋白A（Con A）刺激的Lyt-2⁺、Ia⁻脾细胞毒性T淋巴细胞（CTL）前体细胞的增殖和分化。如抗IL-2受体阻断单克隆抗体无抑制作用所示，对IL-4和Con A的反应不依赖于培养物中假定的内源性IL-2产生。我们的结果表明，IL-2和IL-4可支持凝集素刺激的Lyt-2⁺ T淋巴细胞产生同等的增殖反应，而IL-4在刺激它们分化为成熟的具有细胞溶解活性的细胞方面更有效。
相似文献
1
B cell stimulatory factor 1 (interleukin 4) is sufficient for the proliferation and differentiation of lectin-stimulated cytolytic T lymphocyte precursors.B细胞刺激因子1（白细胞介素4）足以使凝集素刺激的细胞毒性T淋巴细胞前体增殖和分化。
J Exp Med. 1987 Nov 1;166(5):1464-70. doi: 10.1084/jem.166.5.1464.
2
3
Signal requirements for the in vitro differentiation of cytotoxic T lymphocytes (CTL): distinct soluble mediators promote preactivation of CTL-precursors, clonal growth and differentiation into cytotoxic effector cells.细胞毒性T淋巴细胞（CTL）体外分化的信号要求：不同的可溶性介质促进CTL前体细胞的预激活、克隆生长以及分化为细胞毒性效应细胞。
Eur J Immunol. 1985 May;15(5):472-8. doi: 10.1002/eji.1830150511.
4
Monoclonal anti-Lyt-2 antibodies block the activation of cytolytic T lymphocyte precursors.单克隆抗Lyt-2抗体可阻断细胞毒性T淋巴细胞前体的激活。
J Immunol. 1983 Apr;130(4):1552-5.
5
IL-10: a novel cytotoxic T cell differentiation factor.白细胞介素-10：一种新型细胞毒性T细胞分化因子。
J Immunol. 1991 Jul 15;147(2):528-34.
6
Interleukin 2 induces both, growth and maturation of lectin reactive Lyt-2+ but not Lyt-2-precursor cells and regulates the cytolytic potential of effector cells.白细胞介素2可诱导凝集素反应性Lyt-2+细胞而非Lyt-2-前体细胞的生长和成熟，并调节效应细胞的细胞溶解潜能。
Immunobiology. 1986 Apr;171(3):274-301. doi: 10.1016/S0171-2985(86)80010-9.
7
Requirement for three distinct lymphokines for the induction of cytotoxic T lymphocytes from thymocytes.从胸腺细胞诱导细胞毒性T淋巴细胞需要三种不同的淋巴因子。
J Immunol. 1986 Dec 1;137(11):3494-500.
8
9
10
Differential requirements for activation and growth of unprimed cytotoxic and helper T lymphocytes.未致敏细胞毒性T淋巴细胞和辅助性T淋巴细胞激活与生长的不同需求。
Eur J Immunol. 1983 Sep;13(9):719-25. doi: 10.1002/eji.1830130906.
引用本文的文献
1
Association of Polymorphisms with Allergic Rhinitis in Jordanian Population.约旦人群中多态性与过敏性鼻炎的关联。
Medicina (Kaunas). 2020 Apr 14;56(4):179. doi: 10.3390/medicina56040179.
2
Potent intestinal Th17 priming through peripheral lipopolysaccharide-based immunization.通过外周脂多糖免疫增强肠道 Th17 细胞的初始免疫应答。
J Leukoc Biol. 2010 Jul;88(1):21-31. doi: 10.1189/jlb.0909631. Epub 2010 Feb 3.
3
Interleukin-4 diminishes CD8(+) respiratory syncytial virus-specific cytotoxic T-lymphocyte activity in vivo.白细胞介素-4在体内可降低呼吸道合胞病毒特异性细胞毒性CD8(+) T淋巴细胞的活性。
J Virol. 1999 Nov;73(11):8944-9. doi: 10.1128/JVI.73.11.8944-8949.1999.
4
Endogenous interleukin-4, but not interleukin-10, is involved in suppression of host resistance against Listeria monocytogenes infection in interferon-depleted mice.内源性白细胞介素-4而非白细胞介素-10参与了干扰素缺乏小鼠对单核细胞增生李斯特菌感染的宿主抵抗力抑制过程。
Infect Immun. 1996 Apr;64(4):1252-8. doi: 10.1128/iai.64.4.1252-1258.1996.
5
The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.抗原剂量对T细胞受体αβ转基因模型中CD4 +辅助性T细胞表型发育的影响。
J Exp Med. 1995 Nov 1;182(5):1579-84. doi: 10.1084/jem.182.5.1579.
6
Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles.极化抗原特异性CD8效应细胞群体的产生：白细胞介素（IL）-4和IL-12在促进2型与1型细胞因子谱中的相互作用。
J Exp Med. 1994 Nov 1;180(5):1715-28. doi: 10.1084/jem.180.5.1715.
7
Interactions between receptors for interleukin 2 and interleukin 4 on lines of helper T cells (HT-2) and B lymphoma cells (BCL1).辅助性T细胞系（HT-2）和B淋巴瘤细胞系（BCL1）上白细胞介素2受体与白细胞介素4受体之间的相互作用。
J Exp Med. 1989 Feb 1;169(2):379-91. doi: 10.1084/jem.169.2.379.
8
Endogenously secreted IL-4 is required for mouse thymocytes to become cytotoxic. Human, but not mouse, IL-2 induces a functionally immature thymic subset to secrete IL-4 and become CTL.内源性分泌的白细胞介素-4是小鼠胸腺细胞产生细胞毒性所必需的。人白细胞介素-2（而非小鼠白细胞介素-2）可诱导功能不成熟的胸腺亚群分泌白细胞介素-4并成为细胞毒性T淋巴细胞。
Immunology. 1990 Aug;70(4):478-84.
9
10
Interleukin-4 augments the cytotoxic capacity of lymphocytes and monocytes in antibody-dependent cellular cytotoxicity.白细胞介素-4增强淋巴细胞和单核细胞在抗体依赖性细胞毒性中的细胞毒性能力。
Cancer Immunol Immunother. 1991;33(1):45-9. doi: 10.1007/BF01742527.
本文引用的文献
1
The biochemistry, biology, and role of interleukin 2 in the induction of cytotoxic T cell and antibody-forming B cell responses.白细胞介素2在诱导细胞毒性T细胞和抗体形成B细胞反应中的生物化学、生物学及作用。
Immunol Rev. 1982;63:129-66. doi: 10.1111/j.1600-065x.1982.tb00414.x.
2
Dissection of the proliferative and differentiative signals controlling murine cytotoxic T lymphocyte responses.对控制小鼠细胞毒性T淋巴细胞反应的增殖和分化信号的剖析。
J Exp Med. 1982 Jun 1;155(6):1876-81. doi: 10.1084/jem.155.6.1876.
3
Identification of a T cell-derived b cell growth factor distinct from interleukin 2.一种不同于白细胞介素2的T细胞源性B细胞生长因子的鉴定。
J Exp Med. 1982 Mar 1;155(3):914-23. doi: 10.1084/jem.155.3.914.
4
Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function.Lyt表型的意义：Lyt2抗体可阻断识别1类主要组织相容性复合体抗原的T细胞的活性，无论其功能如何。
Proc Natl Acad Sci U S A. 1981 Nov;78(11):7101-5. doi: 10.1073/pnas.78.11.7101.
5
Monoclonal antibody directed against interleukin 2. I. Inhibition of T lymphocyte mitogenesis and the in vitro differentiation of alloreactive cytolytic T cells.抗白细胞介素2单克隆抗体。I. 抑制T淋巴细胞有丝分裂及同种异体反应性细胞毒性T细胞的体外分化。
J Exp Med. 1981 Sep 1;154(3):983-8. doi: 10.1084/jem.154.3.983.
6
A differentiation factor required for the expression of cytotoxic T-cell function.细胞毒性T细胞功能表达所需的分化因子。
Nature. 1982 Apr 22;296(5859):754-7. doi: 10.1038/296754a0.
7
A rapid, large scale purification procedure for gibbon interleukin 2.一种用于长臂猿白细胞介素2的快速大规模纯化方法。
J Immunol. 1983 Aug;131(2):810-5.
8
The role of accessory cells in polyclonal T cell activation. I. Both induction of interleukin 2 production and of interleukin 2 responsiveness by concanavalin A are accessory cell dependent.辅助细胞在多克隆T细胞激活中的作用。I. 伴刀豆球蛋白A诱导白细胞介素2产生以及诱导白细胞介素2反应性均依赖于辅助细胞。
Eur J Immunol. 1983 Jan;13(1):1-6. doi: 10.1002/eji.1830130103.
9
10
Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells.针对单个克隆辅助性T细胞系特有的决定簇的单克隆抗体和抗血清，在T细胞激活过程中都可以替代抗原和抗原呈递细胞。
J Exp Med. 1983 Sep 1;158(3):836-56. doi: 10.1084/jem.158.3.836.
Zotero 插件