一种不同于白细胞介素2的T细胞源性B细胞生长因子的鉴定。
Identification of a T cell-derived b cell growth factor distinct from interleukin 2.
作者信息
Howard M, Farrar J, Hilfiker M, Johnson B, Takatsu K, Hamaoka T, Paul W E
出版信息
J Exp Med. 1982 Mar 1;155(3):914-23. doi: 10.1084/jem.155.3.914.
Abstract
We report here a factor (B cell growth factor) found in induced supernatants of the mouse thymoma EL4 that co-stimulates with anti-IgM antibodies in short-term cultures of purified B lymphocytes to induce polyclonal B cell proliferation but not antibody-forming cell production. The factor is not mitogenic for resting B cells and interacts with anti-IgM-activated B cells in a non-H-2-restricted manner. Absorption studies and molecular weight analysis reveal the factor is distinct from interleukin 2. This factor synergises with antigen, interleukin 2, and an interleukin 2-free, B cell growth factor-free T cell supernatant that contains T cell-replacing factor to produce erythrocyte-specific plaque-forming cells in cultures of highly purified B cells.
摘要
我们在此报告一种在小鼠胸腺瘤EL4诱导上清液中发现的因子（B细胞生长因子），在纯化的B淋巴细胞短期培养中，它与抗IgM抗体共同刺激，诱导多克隆B细胞增殖，但不诱导抗体形成细胞产生。该因子对静止B细胞无促有丝分裂作用，且以非H-2限制的方式与抗IgM激活的B细胞相互作用。吸收研究和分子量分析表明该因子与白细胞介素2不同。在高度纯化的B细胞培养中，该因子与抗原、白细胞介素2以及一种不含白细胞介素2和B细胞生长因子但含有T细胞替代因子的T细胞上清液协同作用，产生红细胞特异性空斑形成细胞。
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