Mineura K, Yasuda T, Kowada M, Ogawa T, Shishido F, Uemura K
Neurosurgical Service, Akita University Hospital, Japan.
J Neurooncol. 1987;5(3):277-85. doi: 10.1007/BF00151232.
Hemocirculatory and metabolic changes in tumor regions and the remote brain structure were analyzed using oxygen-15 and fluorine-18 positron emission tomography (PET) in eight patients with gliomas after radiation and chemotherapy of 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) and N-(2-tetrahydrofuryl)-5-fluorouracil (FT-207). In the tumor regions after the radiochemotherapy, regional cerebral blood flow (rCBF) and cerebral blood volume (rCBV) varied widely and there was a tendency for oxygen consumption (rCMRO2) to fall. The change in glucose consumption (rCMRG1) was especially noteworthy with regard to clinical correlations. Six patients with decreased rCMRG1 values had 16% to 29% regressions in tumor size measured by X-ray computerized tomography (CT), and showed some period of clinical relief. In contrast, one patient with an increased rCMRG1 value had some progression of tumor growth, and there were no clinical amelioration. The hemocirculation and metabolism of the contralateral gray matter seem to fluctuate by various factors as intracranial pressure and the effectiveness of the therapy. In gliomas therapy, tumor rCMRG1 values can be a good indicator of therapeutic effectiveness.
在8例接受1-(4-氨基-2-甲基-5-嘧啶基)甲基-3-(2-氯乙基)-3-亚硝基脲盐酸盐（ACNU）和N-(2-四氢呋喃基)-5-氟尿嘧啶（FT-207）放疗及化疗的神经胶质瘤患者中，使用氧-15和氟-18正电子发射断层扫描（PET）分析肿瘤区域及远处脑结构的血液循坏和代谢变化。放化疗后肿瘤区域的局部脑血流量（rCBF）和脑血容量（rCBV）变化很大，氧耗量（rCMRO2）有下降趋势。葡萄糖消耗量（rCMRG1）的变化在临床相关性方面尤其值得注意。6例rCMRG1值降低的患者，经X线计算机断层扫描（CT）测量肿瘤大小缩小了16%至29%，并出现了一段时间的临床缓解。相比之下，1例rCMRG1值升高的患者肿瘤生长有所进展，且无临床改善。对侧灰质的血液循环和代谢似乎受颅内压及治疗效果等多种因素影响而波动。在神经胶质瘤治疗中，肿瘤rCMRG1值可作为治疗效果的良好指标。
