通过[18F]氟脱氧葡萄糖和正电子发射断层扫描测量脑胶质瘤的葡萄糖利用情况。

Glucose utilization of cerebral gliomas measured by [18F] fluorodeoxyglucose and positron emission tomography.

作者信息

Di Chiro G, DeLaPaz R L, Brooks R A, Sokoloff L, Kornblith P L, Smith B H, Patronas N J, Kufta C V, Kessler R M, Johnston G S, Manning R G, Wolf A P

出版信息

Neurology. 1982 Dec;32(12):1323-9. doi: 10.1212/wnl.32.12.1323.

DOI:10.1212/wnl.32.12.1323

PMID:6983044

Abstract

Positron emission tomography was used to measure local cerebral glucose utilization by the 1-[18F]fluoro-2-deoxy-D-glucose technique in 23 patients with cerebral gliomas. All 10 high-grade (III and IV) astrocytomas demonstrated a region of high activity with a glucose consumption of 7.4 +/- 3.5 (SD) mg/100 gm per minute. The 13 low-grade (I and II) gliomas had a glucose metabolic rate of 4.0 +/- 1.8 mg/100 gm per minute, with no distinctly visible hot spot. Thus, we found a correlation between rate of glycolysis and malignancy in primary cerebral tumors. Cerebral cortical glucose utilization was often depressed in areas adjacent to or neurally connected to the tumor site, and there was focal irregular delta wave EEG activity in these areas.

摘要

采用正电子发射断层扫描术，通过1-[18F]氟-2-脱氧-D-葡萄糖技术测量了23例脑胶质瘤患者的局部脑葡萄糖利用率。所有10例高级别（III级和IV级）星形细胞瘤均显示出一个高活性区域，葡萄糖消耗量为每分钟7.4±3.5（标准差）mg/100g。13例低级别（I级和II级）胶质瘤的葡萄糖代谢率为每分钟4.0±1.8mg/100g，无明显可见的热点。因此，我们发现原发性脑肿瘤的糖酵解速率与恶性程度之间存在相关性。肿瘤部位相邻或神经相连区域的大脑皮质葡萄糖利用率常降低，且这些区域存在局灶性不规则δ波脑电图活动。