Grynpas M D, Simmons E D, Carnes D, Gundberg C, Pritzker K P
Department of Pathology, University of Toronto, Ontario, Canada.
J Orthop Res. 1987;5(4):586-91. doi: 10.1002/jor.1100050414.
The effects of castration on cortical bone structure and chemistry were studied in male Wistar rats of two age groups, 8 and 24 months. Some rats were castrated and some were sham operated (control) in each group. All animals were killed after 4 months. Although no changes in serum chemistry, bone chemistry, or bone histology could be found, the young castrated animals versus controls showed less density of bone mineral as determined by the density fractionation technique and smaller crystallite size of mineral particles as determined by x-ray diffraction line-broadening analysis. These changes, indicative of less mature bone formation, were not observed in mature castrated or control rats despite a decreased amount of bone compared with young rats. In this model, castration appears to affect bone mineral quality in young but not in old animals.
研究了去势对两个年龄组（8个月和24个月）雄性Wistar大鼠皮质骨结构和化学成分的影响。每组中一些大鼠接受去势手术，一些接受假手术（对照）。4个月后处死所有动物。尽管在血清化学、骨化学或骨组织学方面未发现变化，但通过密度分级技术测定，年轻去势动物与对照相比，骨矿物质密度较低，通过X射线衍射线宽分析测定，矿物质颗粒的微晶尺寸较小。这些表明骨形成不太成熟的变化，在成熟去势或对照大鼠中未观察到，尽管与年轻大鼠相比骨量有所减少。在这个模型中，去势似乎影响年轻动物而非老年动物的骨矿物质质量。
