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P-元件诱导的类无翅睾丸蛋白1表达升高预示多种癌症患者预后不良。

Elevated P-Element-Induced Wimpy-Testis-Like Protein 1 Expression Predicts Unfavorable Prognosis for Patients with Various Cancers.

作者信息

Jiang Kehua, Ye Tao, Du Juan, Tang Lanlan, Chen Xiaolong, Sun Fa, Sun Xifeng

机构信息

Department of Urology, Guizhou Provincial People's Hospital, Guiyang 550002, China.

Medical College of Guizhou University, Guiyang, China.

出版信息

J Oncol. 2021 Dec 31;2021:9982192. doi: 10.1155/2021/9982192. eCollection 2021.

DOI:10.1155/2021/9982192
PMID:35003260
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8741353/
Abstract

Increasing evidence has shown that overexpression of P-element-induced wimpy-testis (PIWI)-like protein 1 (PIWIL1) was associated with unfavorable prognosis of patients with various types of cancers. Herein, we conducted this meta-analysis to identify the clinicopathological and prognostic value of the PIWIL1 expression in cancers. Three electronic databases (PubMed, Web of Science, and Embase) were comprehensively retrieved for relevant studies up to August 4, 2019. RevMan 5.3 and STATA 12.0 statistical software programs were used to explore the relationships between PIWIL1 expression and the prognosis and clinicopathological features in cancer patients. A total of 13 studies recruiting 2179 patients with 9 types of solid tumors were finally included in the meta-analysis. The results indicated that patients with high PIWIL1 expression tended to have a shorter survival, and additionally deeper tumor invasion, higher clinical stage, and more lymph node metastasis. PIWIL1 could serve as a biomarker for prognosis and clinicopathological characteristics in various cancers.

摘要

越来越多的证据表明，P元件诱导的弱精睾丸（PIWI）样蛋白1（PIWIL1）的过表达与各类癌症患者的不良预后相关。在此，我们进行了这项荟萃分析，以确定PIWIL1表达在癌症中的临床病理及预后价值。全面检索了三个电子数据库（PubMed、Web of Science和Embase），以获取截至2019年8月4日的相关研究。使用RevMan 5.3和STATA 12.0统计软件程序来探讨PIWIL1表达与癌症患者预后及临床病理特征之间的关系。最终，共有13项纳入2179例9种实体瘤患者的研究被纳入荟萃分析。结果表明，PIWIL1高表达的患者往往生存期较短，此外还伴有更深的肿瘤浸润、更高的临床分期和更多的淋巴结转移。PIWIL1可作为各种癌症预后及临床病理特征的生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae3f/8741353/f195199c2461/JO2021-9982192.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae3f/8741353/d9d44354ce2d/JO2021-9982192.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae3f/8741353/702176fccab7/JO2021-9982192.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae3f/8741353/ef99927e7482/JO2021-9982192.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae3f/8741353/0084d2833d4a/JO2021-9982192.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae3f/8741353/fbab2cf33f31/JO2021-9982192.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae3f/8741353/f195199c2461/JO2021-9982192.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae3f/8741353/d9d44354ce2d/JO2021-9982192.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae3f/8741353/702176fccab7/JO2021-9982192.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae3f/8741353/ef99927e7482/JO2021-9982192.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae3f/8741353/0084d2833d4a/JO2021-9982192.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae3f/8741353/fbab2cf33f31/JO2021-9982192.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae3f/8741353/f195199c2461/JO2021-9982192.006.jpg

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