Department of Urology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Dis Markers. 2021 Dec 31;2021:9494619. doi: 10.1155/2021/9494619. eCollection 2021.
To investigate the relationship between the long noncoding RNA (lncRNA) () and the clinical characteristics of prostate cancer and immune cell infiltration.
The relationship between expression and the clinicopathological characteristics of prostate cancer was analyzed based on The Cancer Genome Atlas (TCGA) database. Receiver operating characteristic (ROC) curves were used to evaluate the value of as a diagnostic marker for prostate cancer. The relationship between and immune cell infiltration was analyzed to explore the effect of on the immune-related functions of prostate cancer.
The ROC curve showed that had a significant diagnostic ability (area under curve = 0.818) for prostate cancer. A reduced expression of in prostate cancer was related to T stage, N stage, primary therapy outcome, residual tumor, Gleason score, and age. The expression of was independently associated with the progression-free interval in prostate cancer patients. The infiltration of immune cells in prostate cancer showed a significant negative correlation between the expression of and plasmacytoid dendritic cells, activated dendritic cells, regulatory T cells, and neutrophils.
is highly expressed in prostate cancer and is expected to be a diagnostic marker. might promote the development of prostate cancer through chemokines, antimicrobials, and cytokines that affect the infiltration of immune cells.
研究长链非编码 RNA () 与前列腺癌临床特征和免疫细胞浸润的关系。
基于癌症基因组图谱 (TCGA) 数据库分析表达与前列腺癌临床病理特征的关系。采用受试者工作特征 (ROC) 曲线评估作为前列腺癌诊断标志物的价值。分析与免疫细胞浸润的关系，探讨对前列腺癌免疫相关功能的影响。
ROC 曲线显示具有显著的前列腺癌诊断能力 (曲线下面积=0.818)。在前列腺癌中表达降低与 T 分期、N 分期、初始治疗效果、残留肿瘤、Gleason 评分和年龄有关。在前列腺癌患者中，的表达与无进展生存期独立相关。前列腺癌中免疫细胞的浸润与浆细胞样树突状细胞、活化的树突状细胞、调节性 T 细胞和中性粒细胞的表达呈显著负相关。
在前列腺癌中高表达，有望成为诊断标志物。可能通过影响免疫细胞浸润的趋化因子、抗菌肽和细胞因子促进前列腺癌的发展。
